An Efficacy and Safety Study of LYC-30937-EC in Subjects With Active Ulcerative Colitis

Completed · Phase 2 · Has a placebo group

Conditions studied: Colitis, Ulcerative

In brief

The purpose of the study is to evaluate the efficacy and safety of LYC-30937-EC given orally once daily in subjects with active ulcerative colitis (UC) defined as a total Mayo score (TMS) of 4-11 inclusive, with an endoscopic score of ≥ 2 and a rectal bleeding score of ≥ 1 at screening.

Key facts

Study ID

NCT02762500

Run by

Lycera Corp.

People needed

124

Starts

2016-07-01

Expected to finish

2018-05-01

Last updated by the study team

2019-04-02

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical UC diagnosis ≥ 6 months prior to screening with minimum disease extent of ≥ 15cm from anal verge.
• Active UC defined as a TMS of 4-11 (inclusive) with endoscopic subscore of ≥ 2 and rectal bleeding subscore of ≥ 1 at screening.
• Females of childbearing potential must have a negative pregnancy test at screening and baseline visits and must agree to use acceptable methods of birth control while in the trial and for 30 days after taking the last dose of study drug.
• May be currently receiving treatment with oral aminosalicylates (ASA) for ≥ 6 weeks at a stable dose for ≥ 3 weeks prior to the screening screening endoscopy and/or thiopurine at a stable dose ≥ 8 weeks prior to the screening endoscopy and/or prednisone (dose 20 mg daily) or equivalent for ≥ 4 weeks and receiving stable dose for ≥ 2 weeks prior to screening endoscopy
• able to provide written informed consent and be compliant with study procedures.

You may not qualify if…

• History of Crohn's disease (CD) or indeterminate colitis or the presence or history of fistula consistent with CD.
• Presence of colon polyps.
• Severe extensive disease that in the investigators discretion is likely to require colonic surgery during the 8 week double-blind portion of the trial (eg, fulminant colitis, toxic megacolon, bowel perforation, evidence of acute abdomen).
• History of alcohol or drug abuse within 1 year of randomization.
• History of cancer including solid tumors and hematological malignancies (except basal cell and in situ squamous cell carcinomas of the skin that have been adequately treated with no recurrence for ≥ 1 year prior to screening.
• History or currently active primary or secondary immunodeficiency.
• Clinically relevant hepatic, neurologic, pulmonary, ophthalmological, gastrointestinal, endocrine, psychiatric, or other major systemic disease making implementation of the study difficult or that would put the subject at risk by participating in the study
• Positive test for Clostridium difficile or positive stool culture for enteric pathogens or presence of ova or parasites at screening.
• Liver function tests > 1.5 x upper limit of normal (ULN) or direct bilirubin > 1.5 x ULN
• Hemoglobin < 8.5 g/dl
• Neutrophils < 1500/mm3
• White blood cell (WBC) count < 3000/mm3
• Platelets < 80000 mm3
• International normalized ratio (INR) > 1.5
• Treatment with an immunosuppressant agent within 8 weeks of screening.
• Previous exposure to ≥ 2 approved or investigational biologic agents to treat UC.
• History of UC treatment with a biologic agent within 12 weeks of screening.
• Treatment with rectal steroids within 2 weeks of screening.
• Treatment with an investigational agent within 30 days of screening.

Where it is running

• Lycera Investigational Site — Long Beach, California, United States
• Lycera Investigational Site — Mission Hills, California, United States
• Lycera Investigational Site — Rialto, California, United States
• Lycera Investigational Site — Hollywood, Florida, United States
• Lycera Investigational Site — Miami, Florida, United States
• Lycera Investigational Site — Decatur, Georgia, United States
• Lycera Investigational Site — Marietta, Georgia, United States
• Lycera Investigational Site — Chicago, Illinois, United States
• Lycera Investigational Site — Louisville, Kentucky, United States
• Lycera Investigational Site — Baton Rouge, Louisiana, United States
• Lycera Investigational Site — Ann Arbor, Michigan, United States
• Lycera Investigational Site — Brooklyn, New York, United States
• Lycera Investigational Site — New York, New York, United States
• Lycera Investigational Site — The Bronx, New York, United States
• Lycera Investigational Site — Greenville, North Carolina, United States
• Lycera Investigational Site — Flourtown, Pennsylvania, United States
• Lycera Investigational Site — Philadelphia, Pennsylvania, United States
• Lycera Investigational Site — Sayre, Pennsylvania, United States
• Lycera Investigational Site — Nashville, Tennessee, United States
• Lycera Investigational Site — Union City, Tennessee, United States
• Lycera Investigational Site. — Houston, Texas, United States
• Lycera Investigational Sites — Houston, Texas, United States
• Lycera Investigational Site — Houston, Texas, United States
• Lycera Investigational Site — Houston, Texas, United States
• Lycera Investigational Site — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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