The Effect of Vasopressin on Glucose Regulation
Completed · Not applicable
Conditions studied: Insulin Resistance
In brief
Data from experimental animals and human epidemiological studies have suggested that hypohydration and/or low water intake is linked to poor glucose regulation and diabetes. The aim of this study is to investigate the effects of cellular dehydration on glucose in healthy non-diabetic individuals. METHODS: 60 males and females (30-55 y) will will undergo two experimental trials (ISO and HYP), consisting of a 2-h intravenous infusion of isotonic or hypertonic saline on two separate occasions, followed by a 4-h oral glucose tolerance test. Blood samples were taken from an antecubital vein in 30-min intervals starting at baseline for assessment of fluid and glucose regulating factors. Thirst will be assessed via visual analog following each blood sample. Energy substrate oxidation will be calculated via indirect calorimetry every 60 min.
Key facts
- Study ID
- NCT02761434
- Run by
- University of Arkansas, Fayetteville
- People needed
- 60
- Starts
- 2016-04-13
- Expected to finish
- 2017-05-15
- Last updated by the study team
- 2017-05-31
Who can join
Age: 30 and older, up to 50. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Males or females of age 30-50 y old
- Signed Informed Consent prior to the initiation of any trial procedure
- Sedentary lifestyle
You may not qualify if…
- Body Mass Index (BMI) greater than 35 kg/m2, below 18.5 kg/m2, and between 25 and 28 kg/m2
- Surgical operation on digestive tract, except possible appendectomy
- Regular smoker within the past 6 months
- Diagnosed diabetes (Type I or Type II)
- Previous diagnosis of cardiovascular disease including hypertension
- Inability to participate in the entire study
- Drastic change in weight in the last month (more than 3 kg)
- Serotonin re-uptake inhibitors (i.e. Prozac)
- Impaired kidney or liver function
- Insulin therapy
- injectable contraceptives
- Currently taking medications that impair water balance
- Commuting by bike the day of the experiment
- Pregnancy
Where it is running
- University of Arkansas — Fayetteville, Arkansas, United States
Full record on ClinicalTrials.gov
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