Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department

Completed · Phase 4 · Has a placebo group

Conditions studied: Nausea

In brief

This study will compare the efficacy of isopropyl alcohol and conventional anti-emetics with three study arms: (1) inhaled isopropyl alcohol plus oral ondansetron; (2) inhaled isopropyl alcohol plus oral placebo; (3) inhaled placebo plus oral ondansetron.

Key facts

Study ID

NCT02760069

Run by

Brooke Army Medical Center

People needed

122

Starts

2016-01-01

Expected to finish

2017-11-01

Last updated by the study team

2020-07-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ages 18 and older
• complaint of nausea and/or vomiting reported at 3 or above on verbal numerical rating scale at the time of triage

You may not qualify if…

• allergy to isopropyl alcohol or ondansetron
• inability to breathe through nose (e.g., recent upper respiratory infection)
• intake of cefoperazone, disulfiram, or metronidazole within the last 24 hours
• mental status precluding informed consent including intoxication
• known QT-prolongation
• clinical suspicion for serotonin syndrome
• intravenous catheter in place prior to study start
• medications administered since patient arrival (e.g., in triage)

Where it is running

• San Antonio Military Medical Center — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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