Diabetes and Glycosylation in Cervical Spondylosis
Stopped early
Conditions studied: Diabetes, Cervical Myelopathy, Cervical Spondylosis
In brief
The purpose of this study is to determine the relevant significance of diabetes on cervical disc degeneration, and correlate diabetic control (HgbA1C) with disc glycosylation profile in patients undergoing anterior cervical discectomy and fusion for cervical spondylosis. Additionally, to compare the level of degenerative cervical disc glycosylation in patients with and without diabetes. Hypothesis: Patients with diabetes and degenerative cervical disc disease have higher levels of disc tissue glycosylation, and higher levels of glycosylation are correlated with poor outcomes.
Key facts
- Study ID
- NCT02758899
- Run by
- Washington University School of Medicine
- People needed
- 21
- Starts
- 2014-03-01
- Expected to finish
- 2016-08-01
- Last updated by the study team
- 2021-02-10
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-75
- A diagnosis of type I or type II diabetes mellitus (diabetes cohort only)
- Clinical diagnosis of cervical myelopathy or cervical spondylosis
- Requiring anterior cervical discectomy and fusion
- Able to cooperate in the completion of standardized outcome measures (NDI)
- Willing and able to comply with study protocol
- Control patients will fulfill all eligibility criteria with the exception of diagnosis of diabetes.
You may not qualify if…
- Pre-existent neurologic disorder or mental disorder that would preclude accurate evaluation (psychiatric disease, Parkinson's disease, Alzheimer's disease)
- History of previous anterior cervical fusion adjacent to the operative site
- Osteoporosis
- Rheumatoid arthritis
- Pregnancy
- Active malignancy
- History of previous posterior cervical decompression
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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