Standard vs. Ultrasound-assisted Catheter Thrombolysis for Submassive Pulmonary Embolism

Completed · Not applicable

Conditions studied: Pulmonary Embolism

In brief

The study will compare standard catheter directed thrombolysis to ultrasound accelerated thrombolysis for the treatment of acute submassive pulmonary embolism (PE). The study population will include patients eligible for catheter directed thrombolysis (CDT) for submassive PE. Subjects will be randomized to, either, standard catheter-directed thrombolysis or ultrasound-accelerated thrombolysis (USAT).

Key facts

Study ID

NCT02758574

Run by

University of Pittsburgh

People needed

77

Starts

2016-05-01

Expected to finish

2021-08-01

Last updated by the study team

2021-09-05

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• pregnancy;
• index PE symptom duration >14 days;
• high bleeding rsk (any prior intracranial hemorrhage,
• known structural intracranial cerebrovascular disease or neoplasm,
• ischemic stroke within 3 months,
• suspected aortic dissection, active bleeding or bleeding diathesis,
• recent spinal or cranial/brain surgery,
• recent closed-head or facial trauma with bony fracture or brain injury);
• participation in any other investigational drug or device study;
• life expectancy <90 days;
• inability to comply with study assessments.

Where it is running

• UPMC Presbyterian — Pittsburgh, Pennsylvania, United States
• UPMC Mercy — Pittsburgh, Pennsylvania, United States
• UPMC Shadyside — Pittsburgh, Pennsylvania, United States
• UPMC Passavant — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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