Inhibition of Atrial Fibrillation by Elimination of Transitional Mechanisms

Withdrawn before enrolling · Not applicable

Conditions studied: Atrial Fibrillation, Arrhythmia

In brief

There is growing awareness of the importance of electrical rotors to the maintenance of atrial fibrillation (AF). Recent work in our laboratory has found that AF evolves over time, from rapid, focal activation, next to transitional rotors, and finally to stable, long duration rotors, whose locations are frequently separate from the transitional rotor sites. This project will test the hypothesis that mapping and ablation of the transitional rotors sites may prevent atrial fibrillation from progressing to sustained atrial fibrillation, and therefore increase the AF initiation threshold. The investigators will test this hypothesis during clinically-indicated electrophysiology study prior to ablation of symptomatic AF.

Key facts

Study ID

NCT02758002

Run by

University of California, San Diego

People needed

0

Starts

2016-01-28

Expected to finish

2018-12-01

Last updated by the study team

2020-02-28

Who can join

Age: 21 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients with symptomatic atrial fibrillation (AF) undergoing clinically-indicated ablation
• either persistent or paroxysmal AF

You may not qualify if…

• decompensated heart failure;
• non-revascularized coronary ischemia
• LA diameter > 60mm
• inability or refusal to provide consent

Where it is running

• Sulpizio Cardiovascular Center — La Jolla, California, United States

Full record on ClinicalTrials.gov

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