The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure

Completed · Not applicable

Conditions studied: Glaucoma, Open-angle, Hypertension, Ocular

In brief

The aim of this study will be to determine the effects of pilocarpine as an adjunct medication to latanoprost monotherapy at multiple intervals throughout a 24-hour period and compare these effects to latanoprost alone.

Key facts

Study ID

NCT02754570

Run by

University of Colorado, Denver

People needed

27

Starts

2016-07-01

Expected to finish

2018-02-21

Last updated by the study team

2019-11-07

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current confirmed diagnosis of:
• open angle glaucoma, or
• ocular hypertension including pigment dispersion glaucoma, and
• pseudoexfoliation glaucoma.
• Current use of topical latanoprost once a day in both eyes for at least 6 weeks
• any race/ethnicity

You may not qualify if…

• Females who are currently pregnant or planning to become pregnant during the study period
• Diagnosis of any other form of glaucoma other than open-angle
• Intraocular pressure readings of <14mmHg in either eye when measured during routine office visit in the past 12 months.
• Schaffer angle grade < 2 in either eye by gonioscopy
• Intraocular surgery within 6 months or laser within 3 months
• History of retinal tear or detachment in either eye
• Active iritis in either eye as determined by most recent eye examination
• Patients who smoke or have irregular daily sleep patterns
• Patients who have started or changed glucocorticoids therapy in the last 3 months
• Patients who are currently using medical or recreational marijuana
• Any use of a non-FDA approved medication for glaucoma in the last 3 months

Where it is running

• University of Colorado Denver Eye Hospital — Denver, Colorado, United States

Full record on ClinicalTrials.gov

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