A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer

Completed · Phase 3

Conditions studied: Colorectal Cancer

In brief

This is an international multi-center, prospective, open-label, randomized, adaptive design phase 3 trial of the cancer stem cell pathway inhibitor napabucasin plus standard bi-weekly FOLFIRI versus standard bi-weekly FOLFIRI in patients with previously treated metastatic colorectal cancer (CRC).

Key facts

Study ID

NCT02753127

Run by

Sumitomo Pharma America, Inc.

People needed

1253

Starts

2016-06-01

Expected to finish

2021-05-12

Last updated by the study team

2023-11-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written, signed consent for trial participation must be obtained from the patient appropriately in accordance with applicable ICH guidelines and local and regulatory requirements prior to the performance of any study specific procedure.
• Must have histologically confirmed advanced CRC that is metastatic.
• Must have failed treatment with one regimen containing a fluoropyrimidine, oxaliplatin with or without bevacizumab for metastatic disease. All patients must have received a minimum of 6 weeks of the first-line regimen that included bevacizumab (if applicable), oxaliplatin and a fluoropyrimidine in the same cycle. Treatment failure is defined as radiologic progression during or < 6 months after the last dose of first-line therapy.
• FOLFIRI therapy is appropriate for the patient and is recommended by the Investigator.
• Imaging investigations including CT/MRI of chest/abdomen/pelvis or other scans as necessary to document all sites of disease performed within 21 days prior to randomization. Patients with either measurable disease or non-measurable evaluable disease are eligible.
• Must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.
• Must be ≥ 18 years of age.
• For male or female patient of child bearing potential: Must agree to use contraception or take measures to avoid pregnancy during the study and for 180 days for female and male patients, of the final FOLFIRI dose. Patients who receive single agent napabucasin without FOLFIRI must agree to use contraception or take measures to avoid pregnancy during the study and for 30 days for female patients and 90 days for male patients, of the final napabucasin dose.
• Women of child bearing potential (WOCBP) must have a negative serum or urine pregnancy test within 5 days prior to randomization. The minimum sensitivity of the pregnancy test must be 25 IU/L or equivalent units of HCG.
• Must have alanine transaminase (ALT) ≤ 3 × institutional upper limit of normal (ULN) [≤ 5 × ULN in presence of liver metastases] within 14 days prior to randomization.
• Must have hemoglobin (Hgb) ≥ 9.0 g/dL within 14 days prior to randomization. Must not have required transfusion of red blood cells within 1 week of baseline Hgb assessment.
• Must have total bilirubin ≤ 1.5 × institutional ULN [≤ 2.0 x ULN in presence of liver metastases] within 14 days prior to randomization.
• Must have creatinine ≤ 1.5 × institutional ULN or Creatinine Clearance > 50 ml/min (as calculated by the Cockcroft-Gault equation (Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]) within 14 days prior to randomization.
• Must have absolute neutrophil count ≥ 1.5 x 10\^9/L within 14 days prior to randomization.
• Must have platelet count ≥ 100 x 10\^9/L within 14 days prior to randomization. Must not have required transfusion of platelets within 1 week of baseline platelet assessment.
• Patient must have adequate nutritional status with Body Mass Index (BMI) > 18 kg/m\^2 and body weight of > 40 kg with serum albumin > 3 g/dL.
• Other baseline laboratory evaluations, listed in Section 6.0, must be done within 14 days prior to randomization.
• Patient must consent to provision of, and Investigator(s) must confirm access to and agree to submit a representative formalin fixed paraffin block of tumor tissue in order that the specific biomarker assays may be conducted. Submission of the tissue is to occur prior to randomization, unless approved by the Sponsor. Where local center regulations prohibit submission of blocks of tumor tissue, two 2 mm cores of tumor from the block and 10-30 unstained slides of whole sections of representative tumor tissue are preferred. Where two 2 mm cores of tumor from the block are unavailable, 10-30 unstained slides of whole sections of representative tumor tissue alone are acceptable. Where no previously resected or biopsied tumor tissue exists or is available, on the approval of the Sponsor/designated CRO, the patient may still be considered eligible for the study.
• Patient must consent to provision of a sample of blood in order that the specific correlative marker assays may be conducted.
• Patients must be accessible for treatment and follow-up. Patients registered on this trial must receive protocol treatment and be followed at the participating center. This implies there must be reasonable geographical limits placed on patients being considered for this trial. Investigators must ensure that the patients randomized on this trial will be available for complete documentation of the treatment, response assessment, adverse events, and follow-up.
• Protocol treatment is to begin within 2 calendar days of patient randomization.
• The patient is not receiving therapy in a concurrent clinical study and the patient agrees not to participate in other interventional clinical studies during their participation in this trial while on study treatment. Patients participating in surveys or observational studies are eligible to participate in this study.

You may not qualify if…

• Anti-cancer chemotherapy or biologic therapy if administered prior to the first planned dose of study medication (napabucasin or FOLFIRI) within period of time equivalent to the usual cycle length of the regimen. An exception is made for oral fluoropyrimidines (e.g. capecitabine, S-1), where a minimum of 10 days since last dose must be observed prior to the first planned dose of study medication. Standard dose of bevacizumab (5 mg/kg) may be administered prior to FOLFIRI infusion, per Investigator decision, for as long as permanent decision to include or exclude bevacizumab is made prior to patient randomization. Radiotherapy, immunotherapy (including immunotherapy administered for non-malignant diseaseneoplastic treatment purposes), or investigational agents within four weeks of first planned dose of study medication, with the exception of a single dose of radiation up to 8 Gy (equal to 800 RAD) with palliative intent for pain control up to 14 days before randomization.
• More than one prior chemotherapy regimen administered in the metastatic setting.
• Major surgery within 4 weeks prior to randomization.
• Patients with any known brain or leptomeningeal metastases are excluded, even if treated.
• Women who are pregnant or breastfeeding. Women should not breastfeed while taking study treatment and for 4 weeks after the last dose of napabucasin or while undergoing treatment with FOLFIRI and for 180 days after the last dose of FOLFIRI.
• Gastrointestinal disorder(s) which, in the opinion of the Qualified/Principal Investigator, would significantly impede the absorption of an oral agent (e.g. intestinal occlusion, active Crohn's disease, ulcerative colitis, extensive gastric and small intestine resection).
• Unable or unwilling to swallow napabucasin capsules daily.
• Prior treatment with napabucasin.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, clinically significant non-healing or healing wounds, symptomatic congestive heart failure, unstable angina pectoris, clinically significant cardiac arrhythmia, significant pulmonary disease (shortness of breath at rest or mild exertion), uncontrolled infection or psychiatric illness/social situations that would limit compliance with study requirements.
• Known hypersensitivity to 5-fluorouracil/leucovorin
• Known dihydropyrimidine dehydrogenase (DPD) deficiency
• Known hypersensitivity to irinotecan
• Chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis)
• Patients receiving treatment with St. John's wort or Phenytoin.
• Patients who plan to receive yellow fever vaccine during the course of the study treatment.
• Abnormal glucuronidation of bilirubin, known Gilbert's syndrome
• Patients with QTc interval > 470 milliseconds
• For patients to be treated with a regimen containing bevacizumab:
• History of cardiac disease: congestive heart failure (CHF) > New York Heart Association (NYHA) Class II; active coronary artery disease, myocardial infarction within 6 months prior to study entry; unevaluated new onset angina within 3 months or unstable angina (angina symptoms at rest) or cardiac arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted).
• Current uncontrolled hypertension (systolic blood pressure [BP] > 150 mmHg or diastolic pressure > 90 mmHg despite optimal medical management) as well as prior history of hypertensive crisis or hypertensive encephalopathy.
• History of arterial thrombotic or embolic events (within 6 months prior to study entry)
• Significant vascular disease (e.g., aortic aneurysm, aortic dissection, symptomatic peripheral vascular disease)
• Evidence of bleeding diathesis or clinically significant coagulopathy
• Major surgical procedure (including open biopsy, significant traumatic injury, etc.) within 28 days, or anticipation of the need for major surgical procedure during the course of the study as well as minor surgical procedure (excluding placement of a vascular access device or bone marrow biopsy) within 7 days prior to study enrollment
• Proteinuria at screening as demonstrated by urinalysis with proteinuria ≥ 2+ (patients discovered to have ≥2+ proteinuria on dipstick urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate ≤ 1g of protein in 24 hours to be eligible).

Where it is running

• Mayo Clinic Arizona — Phoenix, Arizona, United States
• Arizona Oncology Associates, PC - HOPE — Tucson, Arizona, United States
• Comprehensive Blood and Cancer Center — Bakersfield, California, United States
• City of Hope- Comprehensive Care Center — Duarte, California, United States
• University of California-San Diego/Moores UCSD Cancer Center — La Jolla, California, United States
• Los Angeles Hematology Oncology Medical Group — Los Angeles, California, United States
• USC Norris Comprehensive Cancer Center — Los Angeles, California, United States
• UCLA Hematology Oncology Santa Monica — Santa Monica, California, United States
• St. Joseph Heritage Healthcare — Santa Rosa, California, United States
• Rocky Mountain Cancer Centers — Denver, Colorado, United States
• St Mary's Hospital & Regional Med Center — Grand Junction, Colorado, United States
• Medical Oncology Hematology Consultants, PA — Newark, Delaware, United States
• Florida Cancer Specialists & Research Institute Fort Myers — Fort Myers, Florida, United States
• Memorial Cancer Institute at Memorial Hospital — Hollywood, Florida, United States
• Baptist Health Medical Group Oncology, LLC — Miami, Florida, United States
• Sarah Cannon Research Institution — St. Petersburg, Florida, United States
• Palm Beach Cancer Institute — West Palm Beach, Florida, United States
• Piedmont Cancer Institute, PC — Atlanta, Georgia, United States
• Emory University/Winship Cancer Institute — Atlanta, Georgia, United States
• Suburban Hematology-Oncology Associates, PC - Lawrenceville — Lawrenceville, Georgia, United States
• Illinois Cancer Specialists — Arlington Heights, Illinois, United States
• Northshore University Healthsystem — Evanston, Illinois, United States
• Healthcare Research Network III, LLC — Tinley Park, Illinois, United States
• Northwestern Medicine Cancer Center — Warrenville, Illinois, United States
• Alabama Oncology — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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