Ketamine Anesthesia for Improvement of Depression in ECT
Completed · Not applicable
Conditions studied: Major Depressive Disorder
In brief
The purpose of this prospective randomized clinical trial is to determine if patients receiving ketamine as a part of general anesthesia during electroconvulsive therapy (ECT) rather than standard of care will have improvement in symptoms of depression after a course of ECT treatments. The investigators hypothesize that utilization of ketamine for induction of general anesthesia during ECT treatments will improve symptoms of depression better than standard care. This study is ONLY open to patients eligible to receive healthcare services through the Department of Veterans Affairs at the VA Puget Sound, which means service in the active military, naval or air service or separation under any condition other than dishonorable. Qualifications for VA health care benefits can be found at va.gov.
Key facts
- Study ID
- NCT02752724
- Run by
- VA Puget Sound Health Care System
- People needed
- 52
- Starts
- 2016-03-01
- Expected to finish
- 2018-04-30
- Last updated by the study team
- 2018-06-06
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- outpatients or inpatients at the Puget Sound VA with diagnosis of major depressive disorder or bipolar 1 or 2 over the age of 18 undergoing index course ECT
You may not qualify if…
- uncontrolled hypertension (blood pressure > 180/90 mmHg at the pre-anesthesia clinic visit)
- renal failure
- neurologic disorders (e.g. epilepsy, space occupying lesions, traumatic brain injuries in the past 6 months)
- myocardial infarction in the past 6 months
- known allergies or adverse reactions to ketamine
- American Society of Anesthesiology Physical Class greater than 3
- concomitant psychosis
- schizophrenia or current abuse of alcohol or illicit substances and pregnancy (any trimester)
Where it is running
- VA Puget Sound Health Care System — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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