Identifying Diuretic Resistance in Patients With Acute Heart Failure

Completed

Conditions studied: Heart Failure

In brief

The study team hypothesizes patients at risk for diuretic resistance can be identified early in their Emergency Department (ED) or hospital stay by evaluating their urine sodium and potassium concentration after an initial dose of IV loop diuretic. The goal of this pilot study is to prospectively study urinary electrolyte excretion and determine patterns of diuretic responsiveness. This study would be utilized to power an interventional study which aims to study alternative methods of treating patients who are identified as having a poor response to diuretics in the ED and hospital. This would be expected to have a significant impact on a patient's hospital course, length of stay and adverse events.

Key facts

Study ID

NCT02751242

Run by

Vanderbilt University

People needed

75

Starts

2016-08-01

Expected to finish

2017-07-31

Last updated by the study team

2017-11-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults over age 18
• Diagnosed with AHF in the ED
• Patient or surrogate provided informed consent

You may not qualify if…

• Systolic Blood pressure < 90 mmHg
• Intravenous diuretic administration prior to enrollment
• Allergy to furosemide and bumetanide
• Currently receiving any form of dialysis

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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