Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP)

Completed · Not applicable · Has a placebo group

Conditions studied: Chronic Rhinosinusitis, Endoscopic Sinus Surgery, Chronic Rhinosinusitis Without Polyps, Oral Steroids

In brief

While oral steroids have been shown to be effective in the management of patients with chronic rhinosinusitis with polyps, its role in treating chronic rhinosinusitis without polyps (CRSsNP) is ambiguous. Despite a lack of strong clinical evidence to suggest a benefit in this disease state, steroids are often prescribed as a component of post-operative care after sinus surgery for patients without polyps. Oral steroids carry with them significant adverse effects, and should be prescribed thoughtfully. The aims of this study are to determine if oral steroids in the peri-operative period improves patient outcomes in CRS without polyps.

Key facts

Study ID

NCT02748070

Run by

Stanford University

People needed

81

Starts

2015-08-01

Expected to finish

2019-07-15

Last updated by the study team

2020-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• CRSsNP as defined by Clinical Practice Guideline (Update) on Adult Sinusitis
• scheduled to undergo endoscopic sinus surgery

You may not qualify if…

• chronic rhinosinusitis with polyps (CRSwNP)
• Aspirin exacerbated respiratory disease
• Cystic fibrosis
• Immunosuppressive states (Human immunodeficiency virus, transplant)
• Oral steroid use within 30 days of surgery

Where it is running

• Stanford University — Stanford, California, United States

Full record on ClinicalTrials.gov

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