DCE-MRI and MBI in Assessing Tumor Response to Chemotherapy in Patients With Triple Negative Breast Cancer
Running, not enrolling · Early Phase 1
Conditions studied: Estrogen Receptor Negative, HER2/Neu Negative, Progesterone Receptor Negative, Triple-Negative Breast Carcinoma
In brief
This early phase I trial studies how well dynamic contrast enhanced molecular resonance imaging (DCE-MRI) and technetium-Tc99m sestamibi molecular breast imaging (MBI) work in assessing tumor response to chemotherapy in patients with triple negative breast cancer (TNBC) who are undergoing chemotherapy. Investigational imaging scans such as MBI and DCE-MRI may help researchers predict which patients may respond to treatment.
Key facts
- Study ID
- NCT02744053
- Run by
- M.D. Anderson Cancer Center
- People needed
- 96
- Starts
- 2016-11-07
- Expected to finish
- 2028-04-30
- Last updated by the study team
- 2026-04-21
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- The patient has proven TNBC, defined by standard pathologic assays as negative for estrogen receptor (ER) and progesterone receptor (PR) (< 10% tumor staining) and negative for human epidermal growth factor 2 (HER2) (immunohistochemistry [IHC] score < 3, gene copy number not amplified)
- TNBC patients who are previously untreated and enrolled in the prospective Institutional Review Board (IRB) approved clinical trial: 2014-0185
- Patients who are able to understand and give consent to participating in the study
You may not qualify if…
- Is pregnant (confirmed by the patient as imaging clinic standard of care) or nursing mother
- Has lesions involving chest wall
- Has known allergy to Tc99m sestamibi
- Has known contraindications to MRI
- Has contraindication to MRI contrast
Where it is running
- Memorial Hermann Memorial City Medical Center — Houston, Texas, United States
- M D Anderson Cancer Center — Houston, Texas, United States
- MD Anderson in Katy — Houston, Texas, United States
- MD Anderson League City — Nassau Bay, Texas, United States
- MD Anderson in Sugar Land — Sugar Land, Texas, United States
- MD Anderson in The Woodlands — The Woodlands, Texas, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.