Pilot Study of Sodium Bicarbonate in Generally Healthy People With Low Bicarbonate

Stopped early · Not applicable

Conditions studied: Chronic Kidney Disease

In brief

The goal of this pilot study is to determine whether oral sodium bicarbonate can raise low serum bicarbonate concentration in people without chronic kidney disease (CKD). Participants will take sodium bicarbonate for six weeks, followed by a four week washout period.

Key facts

Study ID

NCT02743650

Run by

University of Utah

People needed

7

Starts

2016-02-01

Expected to finish

2017-06-14

Last updated by the study team

2018-11-14

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73m2
• Urinary albumin/creatinine ratio < 30 mg/gm
• Serum bicarbonate ≤ 23 mEq/L (average of the two most recent measurements within the past year)
• Age ≥ 50 years

You may not qualify if…

• Blood pressure ≥ 160/100 mm Hg
• Serum potassium < 3.5 mEq/L
• New York Heart Association Class 3 or 4 heart failure symptoms
• Chronic oxygen therapy
• Chronic obstructive pulmonary disease requiring daily bronchodilator or prednisone therapy
• Weight ≥ 160 kg
• Use of sodium bicarbonate, sodium citrate, potassium citrate, or potassium bicarbonate within the previous two weeks.

Where it is running

• VA Salt Lake City Healthcare System — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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