Liraglutide for HIV-associated Neurocognitive Disorder

Stopped early · Phase 4

Conditions studied: HIV Infection, Diabetes Mellitus Type 2, Obesity, Overweight, Metabolic Syndrome

In brief

This study will test the effect of liraglutide on cognitive function in HIV-infected overweight or obese subjects with type 2 diabetes.

Key facts

Study ID

NCT02743598

Run by

Temple University

People needed

4

Starts

2016-09-01

Expected to finish

2018-09-01

Last updated by the study team

2022-07-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• HIV controlled on therapy for at least 12 weeks
• Viral load < 200 copies
• BMI >27 to 45
• Diagnosis of DM type 2 with A1-C >7 to 15
• Participants must be willing to comply with all study related procedures

You may not qualify if…

• Personal or family history of pancreatitis
• Medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2)
• Gastroparesis
• Allergy to liraglutide or any of the active ingredients in liraglutide or other GLP-1 analogue
• Weight loss drugs other than metformin
• Type 1 diabetes mellitus or diabetic ketoacidosis
• Known major cognitive deficit dementia, history of head trauma with loss of consciousness >30 min, history of stroke, current central nervous system (CNS) disorder such as seizures or opportunistic CNS infection
• Renal insufficiency defined as creatinine clearance < 60 mL/min
• Active opportunistic infections
• Pregnancy or breastfeeding
• Unstable cardiovascular disease with hospitalization within 1 year for acute coronary syndrome
• Decompensated heart failure
• Substance abuse
• Active alcohol or opioid substitution therapy
• Serious or unstable medical or psychological conditions that would compromise the subject's safety for successful participation

Where it is running

• Cherie Vaz — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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