RBC Irradiation, Anemia and Gut Injury

Completed

Conditions studied: Anemia, Necrotizing Enterocolitis

In brief

The purpose of this trial is to study the effect that anemia and red blood cell (RBC) transfusions have on oxygen levels in the digestive tracts of extremely low birth weight (ELBW) infants and to look for possible markers in a baby's blood, urine and/or stool that may lead to a better understanding of what makes an ELBW infant at risk for digestive tract problems such as necrotizing enterocolitis.

Key facts

Study ID

NCT02741648

Run by

Emory University

People needed

324

Starts

2016-07-01

Expected to finish

2026-02-19

Last updated by the study team

2026-06-02

Who can join

Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Birth weight ≤1250 grams
• Postnatal age within 7 days of birth

You may not qualify if…

• Infant not expected to live beyond 7 days of life based on assessment of treating neonatologist
• Severe congenital abnormality expected to affect life expectancy
• RBC or platelet transfusion at an outside institution occurring prior to screening
• Maternal refusal to participate

Where it is running

• Grady Memorial Hospital — Atlanta, Georgia, United States
• Emory University Hospital Midtown — Atlanta, Georgia, United States
• Northside Hospital - Neonatology — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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