Uterine Transplant in Absolute Uterine Infertility (AUIF)
Recruiting now · Phase 2/Phase 3
Conditions studied: Female Infertility
In brief
This study will examine the feasibility of initiating a uterine transplant program for Absolute Uterine Factor Infertility (AUFI) at Brigham and Women's Hospital. The investigators plan to screen 30 patients with a goal of enrolling 10 patients. (5 donors and 5 recipients) After careful screening, appropriate candidates will undergo IVF, Uterine Transplantation, Embryo Transfer, Pregnancy and Delivery. Once the uterus is explanted, five years of follow-up is planned.
Key facts
- Study ID
- NCT02741102
- Run by
- Brigham and Women's Hospital
- People needed
- 3
- Starts
- 2026-07-01
- Expected to finish
- 2028-01-01
- Last updated by the study team
- 2026-07-06
Who can join
Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.
You may not qualify if…
- Active smoking, alcohol use or use of illicit drugs
- Inability to comply with required treatment (taking pills, having biopsies, frequent appointments )
- Having a condition that would make pregnancy or taking anti rejection medicines too risky.
- Active infection: Human Immunodeficiency Virus (HIV) , Tuberculosis, Hepatitis B, Hepatitis C
- History of extensive abdominal or pelvic surgery
- History of abnormal Papanicolaou test (PAP smear) or genital warts
- History of pelvic inflammatory disease
- DONOR:Inclusion criteria
- Age over 40 up to age 60
- Has completed having a family
- Previous pregnancies were carried to term (no miscarriages)
- Able to take a birth control pill containing estrogen
- Weight reasonable with BMI (Body Mass Index) of 30 or less
- Good social supports
- Exclusion Criteria:
- Active smoking, alcohol use or use of illicit drugs
- Psychiatric illness
- Cervical or endometrial polyps (growths) or tumors in the uterus muscle
- History of more than 1 Caesarean section
- History of abnormal PAP smear or genital warts
- Internal scarring from extensive abdominal or pelvic surgery
- Hypertension, Coronary artery disease, Chronic Obstructive Lung disease (emphysema) and Diabetes
- Active cancer or incompletely treated cancer
- Active infection including Human Immunodeficiency Disease (HIV) , Tuberculosis, Hepatitis B or Hepatitis C
- Significant history of either blood clots or bleeding tendencies
Where it is running
- Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
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