Online Program to Reduce Depression in MS

Completed · Not applicable

Conditions studied: Multiple Sclerosis

In brief

This is an international, multicenter, randomized controlled trial of an internet-based CBT intervention for depression (Deprexis) conducted in five MS centers in the US and Germany. The trial consists of a three-arm primary trial phase and an extension phase targeted at maintenance.

Key facts

Study ID

NCT02740361

Run by

Charite University, Berlin, Germany

People needed

279

Starts

2017-02-15

Expected to finish

2021-05-01

Last updated by the study team

2025-05-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age > 18
• neurologist-confirmed diagnosis of MS (all forms)
• self-reported depressive symptoms (BDI-Fastscreen > 4)
• fluent in German or English (depending on study site),
• willingness to engage in self-administration of an iCBT intervention for 3 months and complete follow-up
• ability to travel to the outpatient center for two clinical assessments (baseline and month 3)
• internet access at home

You may not qualify if…

• unwilling or unable to consent,
• diagnosis of bipolar or psychosis (as determined by M.I.N.I structured interview),
• substantial neurocognitive impairments such as dementia or autism
• moderate or high risk of suicide (according to MINI module C) or by clinical impression
• very severe depression that would interfere with the ability to participate in the study (based on clinical judgment by the physician at the recruitment site).
• current psychotherapy/behavioral treatments for depression
• started pharmacotherapy for depression within the last 2 months
• MS relapse or steroid treatment in the last 4 weeks
• concurrent participation in another clinical trial that includes an intervention
• refusal to saving, processing and forwarding of pseudonymized data

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States
• University of Missouri, Kansas City — Kansas City, Kansas, United States
• Penn State University — State College, Pennsylvania, United States
• Universitätsklinikum Hamburg-Eppendorf — Hamburg, Free and Hanseatic City of Hamburg, Germany
• Charité University — Berlin, State of Berlin, Germany

Full record on ClinicalTrials.gov

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