Activating and Identifying Neural Responses to Social Rejection: a Combined tDCS and fMRI Study

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

This research study identifies neural pathways regulating negative moods during rejection by combining transcranial direct current stimulation (tDCS) and fMRI in a sample of healthy controls.

Key facts

Study ID

NCT02739789

Run by

Stony Brook University

People needed

19

Starts

2018-02-14

Expected to finish

2018-10-16

Last updated by the study team

2020-07-08

Who can join

Age: 18 and older, up to 25. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy males or females between 18 and 25 years old
• No diagnosis on Axis I by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV. No current, or within the past 5 years.
• Not currently in a romantic relationship
• Ability to understand and follow instructions and oriented to name, time, and place.
• No additional neurologic or psychiatric disorders
• No current use of psychotropic drugs or during past 3 months (except marijuana and alcohol)
• No current use of marijuana or during past 3 weeks
• Not currently abusing alcohol
• No history of alcohol or drug dependence within past 5 years
• A negative urine pregnancy and toxicology screen. Verbal affirmation will be obtained (i.e., "not pregnant" and "not currently using psychotropic drugs or during the past 3 months") during the Screening Visit (Day 1). Urine screen will be obtained on Days 2 and 3. If subject reports that there is a "possibility that she is pregnant" on Day 1 (Screening Visit) a urine pregnancy screen will be performed on that day.
• (Women): If stopped or started oral contraceptives recently, at least 60 days on/off oral contraceptives.

You may not qualify if…

• Left-handed or ambidextrous
• Metallic dental implants
• Metallic objects in the brain/skull
• Medical device implants
• Implanted electronic devices
• History of seizures
• History of strokes
• Unexplained loss of consciousness
• Frequent or severe headaches or neck pain
• Clinically significant, uncontrolled liver, kidney, cardiac, or pulmonary disease
• Terminal medical diagnosis consistent with survival < 1 year
• Pregnancy; childbirth or miscarriage within 6 months, breastfeeding within 6 months of recruitment
• Serious mental impairment. Mini mental state exam of < 23/30
• Chronic skin disease
• Previous experience with transcranial direct current stimulation (tDCS)
• Regular tobacco use or tobacco use within past month
• If using hormonal birth control, taking progestin-only pills (e.g., Cerazette, Ovrette), or Intrauterine devices (Mirena, Skyla), since progestin-only birth controls are more likely to cause mood swings.
• Addition Exclusion Criteria for participating in fMRI:
• Metal anywhere in the body
• Weight over 250 pounds, or girth size incompatible for scanner bore.

Where it is running

• Stony Brook University — Stony Brook, New York, United States

Full record on ClinicalTrials.gov

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