MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty

Completed · Phase 4

Conditions studied: Stiffness Following Total Knee Arthroplasty

In brief

Compare the outcome following manipulation under anesthesia for stiffness in a randomized controlled fashion with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving manipulation alone. Outcomes will include pain, range of motion, as well as subjective outcome scores.

Key facts

Study ID

NCT02739035

Run by

Mayo Clinic

People needed

130

Starts

2016-04-01

Expected to finish

2022-12-01

Last updated by the study team

2023-11-21

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects who have received a primary unilateral TKA for a diagnosis of osteoarthritis.
• MUA's scheduled between 6-10 weeks postoperatively

You may not qualify if…

• Intolerance to NSAIDs
• Renal dysfunction
• Age < 18 or > 90 years
• Primary diagnosis of rheumatoid arthritis
• Patients with a Glomerular Filtration Rate (GFR) <60 as the cut off for Chronic Kidney Disease (CKD) (stage 3 CKD)

Where it is running

• HipKnee Arkansas Foundation — Little Rock, Arkansas, United States
• Colorado Joint Replacement — Denver, Colorado, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Univ. of Nebraska Medical Center — Omaha, Nebraska, United States
• Hospital for Joint Diseases — New York, New York, United States
• Hospital for Special Surgery — New York, New York, United States
• New York - Presbyterian at Columbia University — New York, New York, United States
• OrthoCarolina — Charlotte, North Carolina, United States
• Duke University Medical Ceter, Dept. of Orthopaedics — Durham, North Carolina, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• Joint Implant Surgeons — New Albany, Ohio, United States
• Rothman Institute — Lansdale, Pennsylvania, United States
• Aria 3B Orthopaedic Specialists — Philadelphia, Pennsylvania, United States
• Houston Methodist — Houston, Texas, United States
• University of Utah Orthopaedic Center — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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