Comparing the ADR With Air Insufflation, Water Immersion and Water Exchange During Two-endoscopist Colonoscopy

Completed · Not applicable

Conditions studied: Adenoma

In brief

Interval (missed) cancers and lower than expected mortality reduction of proximal colon cancers in the United States and elsewhere after screening colonoscopy drew attention to quality indicators. Missed adenomas which are more likely to be in the proximal colon may be contributing factors. An independent predictor of the risk of interval cancers is adenoma detection rate. In pilot observations, the investigators showed that water exchange enhanced adenoma detection in the right colon (cecum to hepatic flexure). This prospective, randomized controlled trial will compare water exchange with water immersion and traditional air insufflation in patients undergoing colonoscopy. The investigators test the hypothesis that compared with air insufflation and water immersion, water exchange produces a significantly higher adenoma detection rate in the right colon

Key facts

Study ID

NCT02737514

Run by

Dalin Tzu Chi General Hospital

People needed

371

Starts

2015-12-01

Expected to finish

2020-02-01

Last updated by the study team

2020-05-29

Who can join

Age: 20 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing colonoscopy performed by the participating endoscopists

You may not qualify if…

• obstructive lesions of the colon known before colonoscopy
• massive ascites
• past history of partial colectomy
• refusal to provide written informed consent

Where it is running

• Sepulveda Ambulatory Care Center, Veterans Affairs Greater — North Hills, California, United States
• Dalin Tzu Chi General Hospital — Chiayi City, Taiwan, Taiwan

Full record on ClinicalTrials.gov

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