N-acetylcysteine for Tobacco Use Disorder
Completed · Phase 2 · Has a placebo group
Conditions studied: Nicotine Dependence, Smoking
In brief
The purpose of this study is to assess the effects of administering N-Acetylcysteine (NAC) to assist in initial cessation and/or relapse prevention in adult cigarette smokers.
Key facts
- Study ID
- NCT02737358
- Run by
- Medical University of South Carolina
- People needed
- 114
- Starts
- 2016-08-30
- Expected to finish
- 2019-10-10
- Last updated by the study team
- 2020-08-17
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-65
- Daily smoker for ≥6 months, smoking approximately ≥5 cigarettes per day on average in the past month or must meet the criteria for nicotine dependence
- Be interested in quitting smoking (defined as a 2 or above on a 10-point Likert scale assessing readiness and interest in quitting (1=not at all ready/interested, 10=extremely ready/interested)
- Willing to engage in a 3-day quit attempt as part of study procedures
- Willing to abstain from cannabis use during study procedures (since inhaled cannabis will affect breath carbon monoxide readings).
- If female, agreement to use birth control (any form) to avoid pregnancy during study procedures
You may not qualify if…
- Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than tobacco use disorder) in the past month that may interfere with study performance based on PI judgment
- Current pregnancy or breastfeeding
- Current use of medications with smoking cessation efficacy
- Known hypersensitivity to NAC
- Use of carbamazepine or nitroglycerin (or any other medication deemed to be hazardous if taken with NAC) within 14 days of study participation
Where it is running
- Medical University of South Carolina — Charleston, South Carolina, United States
Full record on ClinicalTrials.gov
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