Metabolic Processes in Adults and Adolescents With Autism Spectrum Disorder
Completed · Not applicable
Conditions studied: Autism Spectrum Disorder
In brief
The objective of this study is to gain preliminary information and knowledge on metabolic profile in ASD. The benefit of this study will be to expand our insight of the potential relationship in metabolic processes and neuropsychological functions in ASD. For example, based on the obtained data of the study we can determine whether there is a link between the tryptophan pathway and cognitive functions in autism. The project is based on a systematic and multidisciplinary approach using tracers for delineating the mechanism by which the metabolism of amino acids like TRP is involved in affective and cognitive functions in ASD. Using an innovative approach to the evaluation of amino acids has not been used in adults with ASD. In addition, the obtained data of the study holds promise to develop specific markers (metabolic and/or neuropsychological) for guiding the identification those individuals with increased risk of developing mood disturbances or cognitive impairment, and for predicting the therapeutic effect of a specific nutritional interventions in subjects with ASD.
Key facts
- Study ID
- NCT02733120
- Run by
- Texas A&M University
- People needed
- 40
- Starts
- 2015-12-03
- Expected to finish
- 2017-10-30
- Last updated by the study team
- 2025-09-30
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Any condition that may interfere with the definition 'healthy subject' according to the investigator's judgment (for healthy group)
- Failure to give informed consent
- Established diagnosis of Insulin Dependent Diabetes Mellitus
- Metabolic diseases, including hepatic or renal disorders
- Presence of acute illness or metabolically unstable chronic illness
- Presence of fever within the last 3 days
- Pre-planned surgery of procedures that would interfere with the conduct of the study
- Any other condition according to the PI or study physician that would interfere with proper conduct of the study / safety of the patient
- Current alcohol or drug abuse
- Use of protein or amino acid containing nutritional supplements within 5 days prior to the study days
- Use of long-term oral corticosteroids or short course of oral cortico-steroids 4 weeks preceding first test day
- Body Mass Index of < 18.5 or ≥ 40 kg/m2
- Montreal Cognitive Assessment score of < 20
Where it is running
- Texas A&M University-CTRAL — College Station, Texas, United States
Full record on ClinicalTrials.gov
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