Cognitive and Behavioral Effects of Sleep Restriction in Adolescents With ADHD

Completed · Not applicable

Conditions studied: Attention Deficit Hyperactivity Disorder

In brief

Adolescents with attention-deficit/hyperactivity disorder (ADHD) obtain less sleep than their typically developing peers. Observational studies indicate that inadequate sleep is correlated with impairment in adolescents with ADHD, but it remains unknown if sleep is causally related to impairment. This study will use an experimental sleep restriction and extension protocol to evaluate sleep as a contributor to clinically significant impairment and possible target for intervention in adolescents with ADHD.

Key facts

Study ID

NCT02732756

Run by

Children's Hospital Medical Center, Cincinnati

People needed

69

Starts

2016-04-21

Expected to finish

2017-08-25

Last updated by the study team

2017-10-12

Who can join

Age: 14 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Between 14 and 17 years of age.
• Estimated IQ ≥ 70.
• Meet full DSM-5 criteria for ADHD.
• Sufficient English language ability necessary to complete study measures.
• If applicable, the family must be willing to discontinue any treatment with a psychostimulant medication during the three-week sleep manipulation protocol.

You may not qualify if…

• Children with an autism spectrum disorder or diagnosed with psychosis, bipolar disorder, or obsessive-compulsive disorder based on the K-SADS diagnostic interview will be excluded.
• Children taking any psychiatric medication that is not a psychostimulant.
• Significant visual, hearing, or speech impairment.
• Organic brain injury or history of seizures.
• Symptoms of obstructive sleep apnea (OSA), periodic limb movement disorder (PLMD), or delayed sleep phase syndrome (DSPS).
• Obligations that require bedtime later than 10pm or waking prior to 5:30am any morning of the study.
• Daily consumption of >1 coffee or "energy drink" or >3 caffeinated sodas.
• Highly atypical sleep, defined as <6 hours or >9.5 hours on school nights per parent and adolescent report.
• Inability or refusal to refrain from automobile driving or other high-risk tasks that require vigilance during the sleep restriction week of the study.
• Finally, at the visit following the baseline week (week 1) of the sleep protocol, we will exclude teens whose actigraphs reflect an inability to consistently arise within 1 hour of the agreed-upon time.

Where it is running

• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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