Ventral Tegmental Area (VTA) Self-Activation in Attention Deficit Hyperactivity Disorder (ADHD)

Completed · Not applicable

Conditions studied: ADHD

In brief

The purpose of this study is to see if a non-medication intervention can increase motivation in individuals with ADHD by observing brain activity using magnetic resonance imaging (MRI).

Key facts

Study ID

NCT02723708

Run by

Duke University

People needed

66

Starts

2016-08-01

Expected to finish

2021-10-05

Last updated by the study team

2023-08-22

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-45 years of age
• Male or Female
• Confirmed diagnosis, any subtype as determined by the clinician administered Conner's Adult ADHD Diagnostic Interview for DSM-IV (CAADID) and clinical interview using the Mini International Neuropsychiatric Interview (MINI)
• T-Score > 65 on one of the DSM-IV relevant scales (Inattentive Symptoms, Hyperactive-Impulsive Symptoms, Total Symptoms or ADHD Index) on both the Self-Report and Observer versions of the Conner's Adult ADHD Rating Scales (CAARS)
• Cognitive functioning eaqual or greater than 80 as assessed by the Kaufman Brief Intelligence test, Second Edition (KBIT-II)

You may not qualify if…

• History of chronic/significant medical condition
• Current or past 6 month use of prescription medications for ADHD or other psychiatric condition
• Meets criteria for any other Axis I Disorder (determined the Mini International Neuropsychiatric Interview (MINI) other than nicotine dependence that is significantly impairing and would contraindicate participation in the present study
• Meets criteria for any Axis II Disorder
• Current substance abuse or dependence or history within the last 12 months; expired breath alcohol level > 0.0; Positive urine drug screen for any of the following: cannabis, amphetamines, opioids, benzodiazepines, barbiturates, cocaine
• Inability to understand written and/or spoken English language
• Claustrophobia or other contraindications to MRI scanning
• If female, pregnancy as determined by urine pregnancy test on each day of MRI scanning
• Presence of any metal in the body (e.g., implant, non-removable piercing, IUD)
• Head injury resulting in loss of consciousness
• Worked with metal (e.g., welding) or had an injury to the eye involving metal
• Weigh more than 250 pounds

Where it is running

• Duke ADHD Program — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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