Behavioral Expressions in Alzheimer's Disease

Completed · Has a placebo group

Conditions studied: Alzheimer's Disease

In brief

Behavioral expressions, such as agitation and aggression, affect up to 90% of persons with dementia and are a major source of patient and caregiver distress, nursing home placement, anti-psychotic medication use, restraints, and increased health care costs. The purpose of the research study is to investigate whether reducing pain reduces behavioral expressions of Alzheimer's disease (agitation and aggression).

Key facts

Study ID

NCT02719834

Run by

University of Florida

People needed

4

Starts

2016-04-01

Expected to finish

2018-02-01

Last updated by the study team

2018-03-02

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• documented diagnosis of Alzheimer's Disease or other dementia
• history of a typically painful condition, such as osteoarthritis, back pain, or other chronic musculoskeletal pain
• able to swallow oral medication
• history of aggressive or agitated behavior (defined as score of > 39 on the Cohen-Mansfield Agitation Inventory),
• Mini Mental State Exam (MMSE) score < 23

You may not qualify if…

• currently taking acetaminophen or opioid medication on a routine (regularly-scheduled, round the clock) basis
• receiving hospice care
• history of liver or renal disease
• drinks more than 3 alcoholic beverages per day
• known allergy or adverse reaction to acetaminophen
• bed-ridden or comatose
• currently taking warfarin

Where it is running

• Oak Hammock Continuing Care Retirement Faculty — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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