Study of Nerve Repair and Reconstruction Associated With Major Extremity Trauma

Completed

Conditions studied: Peripheral Nerve Injury(Ies)

In brief

This is a multi-center prospective observational study that will capture detailed information about the treatment and long term outcomes of 250 patients with PNI resulting from upper extremity trauma. The study will focus on a young adult population to include individuals ages 18-65. Patients with PNI will be recruited during the hospitalization for initial treatment of the upper extremity injury. Additional patients may be identified during clinic visits for on-going treatment of upper extremity injuries as nerve injuries evolve or upon referral from outside physicians. However, all eligible nerve injuries must be treated within 6 months of the initial upper extremity trauma. Outcomes will be assessed at 3, 6, 12, 18 and 24 months following diagnosis of the nerve injury. All assessments will take place in the clinic and will include a patient interview and a brief exam to evaluate sensory and motor function.

Key facts

Study ID

NCT02718768

Run by

Major Extremity Trauma Research Consortium

People needed

242

Starts

2016-03-01

Expected to finish

2024-07-01

Last updated by the study team

2025-01-23

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 18-65
• Sustained a peripheral nerve injury (including iatrogenic injuries and partial nerve injuries) resulting from upper extremity trauma meeting the following criteria:
• Involves injury or dysfunction to motor, or motor and sensory function of the axillary, radial, median, ulnar, or musculocutaneous nerve with injury localized distal to the brachial plexus cord level and proximal to the distal flexion crease of the wrist
• Involves a "mixed" nerve segment (i.e. involves a location of any of the above specified nerves that can be expected to have both sensory and motor axons present) but does not include sensory only distal terminations of the same nerves.
• Receiving surgical treatment (i.e. exploration, neurolysis, repair or reconstruction, nerve or tendon transfer) within 6 months of the initial injury.

You may not qualify if…

• Injuries to the brachial plexus roots, trunks, divisions and cords
• Injuries to the nerves distal to the distal flexion crease of the wrist
• Injuries that involve a distal extension of the parent nerve that is considered sensory only (superficial radial nerve, lateral ante brachial cutaneous nerve, etc)
• Previous motor or sensory deficit prior to injury (e.g. resulting from trauma, stroke, muscular, neurologic, neuromuscular disorder, etc.)
• Documented psychiatric disorder that limits ability to consent and maintain follow-up
• Unable to speak either English or Spanish
• Severe problems with maintaining follow up (e.g patients who are prisoners or homeless at time of injury or who are intellectually challenged without adequate family support).

Where it is running

• Denver Health — Denver, Colorado, United States
• Ryder Trauma Center — Miami, Florida, United States
• Methodist Hospital — Bloomington, Indiana, United States
• University of Maryland Medical Center Shock Trauma Center — Baltimore, Maryland, United States
• The Curtis National Hand Center, Medstar Union Memorial Hospital — Baltimore, Maryland, United States
• Walter Reed National Military Medical Center — Bethesda, Maryland, United States
• Hennepin County Medical Center — Minneapolis, Minnesota, United States
• University of New Mexico Health Sciences Center — Albuquerque, New Mexico, United States
• Carolinas Medical Center — Charlotte, North Carolina, United States
• Wake Forest Baptist Health — Winston-Salem, North Carolina, United States
• MetroHealth — Cleveland, Ohio, United States
• University of Oklahoma Medicine — Oklahoma City, Oklahoma, United States
• Pennsylvania Hospital — Philadelphia, Pennsylvania, United States
• Vanderbilt Medical Center — Nashville, Tennessee, United States
• University of Texas Health Science Center — Houston, Texas, United States
• San Antonio Military Medical Center — San Antonio, Texas, United States
• Virginia Commonwealth University Medical Center — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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