Study of the Efficacy and Safety of Intravitreal (IVT) Aflibercept for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR)
Completed · Phase 3 · Has a placebo group
Conditions studied: Nonproliferative Diabetic Retinopathy
In brief
The primary objective of the study is to assess the efficacy of intravitreal (IVT) aflibercept compared to sham treatment in the improvement of moderately severe to severe nonproliferative diabetic retinopathy (NPDR). The secondary objectives of the study are: * To characterize the safety of IVT aflibercept in patients with moderately severe to severe NPDR * To determine if IVT aflibercept will prevent the worsening of diabetic retinopathy and reduce the incidence of DME * To determine the anatomic effects of IVT aflibercept in patients with moderately severe to severe NPDR
Key facts
- Study ID
- NCT02718326
- Run by
- Regeneron Pharmaceuticals
- People needed
- 402
- Starts
- 2016-03-29
- Expected to finish
- 2019-07-16
- Last updated by the study team
- 2020-07-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Regeneron Study Site — Tucson, Arizona, United States
- Regeneron Study Site — Arcadia, California, United States
- Regeneron Study Site — Beverly Hills, California, United States
- Regeneron Study Site — Encino, California, United States
- Regeneron Study Site — Fullerton, California, United States
- Regeneron Study Site — La Jolla, California, United States
- Regeneron Study Site — Mountain View, California, United States
- Regeneron Study Site — Oakland, California, United States
- Regeneron Study Site — Oceanside, California, United States
- Regeneron Study Site — Sacramento, California, United States
- Regeneron Study Site — Colorado Springs, Colorado, United States
- Regeneron Study Site — Golden, Colorado, United States
- Regeneron Study Site — New London, Connecticut, United States
- Regeneron Study Site — Altamonte Springs, Florida, United States
- Regeneron Study Site — Deerfield Beach, Florida, United States
- Regeneron Study Site — Fort Myers, Florida, United States
- Regeneron Study Site — Lakeland, Florida, United States
- Regeneron Study Site — Largo, Florida, United States
- Regeneron Study Site — Melbourne, Florida, United States
- Regeneron Study Site — Miami, Florida, United States
- Regeneron Study Site — Miami, Florida, United States
- Regeneron Study Site — Orlando, Florida, United States
- Regeneron Study Site — Plantation, Florida, United States
- Regeneron Study Site — Tallahassee, Florida, United States
- Regeneron Study Site — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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