The Effect of HMB Supplementation on Adipose Tissue Inflammation and Metabolism

Stopped early · Not applicable · Has a placebo group

Conditions studied: Obesity

In brief

This study will determine the effects of supplementing beta-hydroxy-beta-methylbutyrate (HMB) on body composition and strength changes during weight loss. When overweight and obese persons lose weight, and in particular in conjunction with dietary restrictions, muscle, bone mass, and muscle strength are also lost. HMB has been shown to preserve muscle mass and strength, and it is thought that HMB may also preserve muscle, bone, and strength during weight-loss.

Key facts

Study ID

NCT02717013

Run by

Metabolic Technologies Inc.

People needed

10

Starts

2016-03-01

Expected to finish

2017-02-01

Last updated by the study team

2017-03-03

Who can join

Age: 18 and older, up to 40. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Male
• Non-smoker
• Body mass index of 35-40 kg/m2
• Age 18-40 years
• Weight stable for past 6 months (<5 lb. change)
• In good health, free of chronic diseases/conditions that may impact measured outcomes
• Willing and able to consume a weight loss diet
• Willing and able to consume a daily nutritional supplement (in pill form)
• Available for scheduled study commitments during the 2 months of study

You may not qualify if…

• Smoke
• Take any cholesterol lowering or weight loss drugs or an drugs or supplements that affect blood lipids, insulin or body composition
• Weigh greater 300 pounds due to weight, size and depth limitations of equipment
• Take dietary supplements
• Have a chronic disease such as:
• Cardiopulmonary disease (e.g. recent myocardial infarction, unstable angina, stroke) or unstable disease
• Severe orthopedic/musculoskeletal or neuromuscular impairments that would contradict exercise
• Sensory impairments that interfere with following directions
• Diagnosis if dementia
• History of malignancy during the past 5 years
• Diabetes mellitus

Where it is running

• Iowa State University — Ames, Iowa, United States

Full record on ClinicalTrials.gov

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