Effects of Adding Raisins to the American Diet on Fecal Microbiota Composition
Completed · Not applicable
Conditions studied: Inflammation
In brief
Raisins contain a significant amount of dietary fiber and polyphenolic compounds that represent an important substrate for microbiota fermentation which generates potentially beneficial end products, such as short-chain fatty acids. The mammalian gut contains a phylogenetically as well as functionally diverse microbiota that contributes to host physiology. To date, little is known about how increased raisin intake affects human gut microbiota composition. This research study will assess the effects of adding raisins to the diet of healthy adults on the bacteria from feces of human subjects and resulting self-reported GI symptoms as well as markers of immune function. The hypothesis is that by adding raisins to the diet this will result in changes in gut microbiota. Furthermore, the changes in microbiota will largely be beneficial, as evaluated by an increase in butyrate producers and bacteria associated with anti-inflammatory properties.
Key facts
- Study ID
- NCT02713165
- Run by
- University of Florida
- People needed
- 18
- Starts
- 2016-01-01
- Expected to finish
- 2016-06-01
- Last updated by the study team
- 2017-09-11
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Good Health
- No systemic antibiotics during the preceding two months
- No medication suppressing immune function
- Willingness to provide basic demographic as well as medical history data
You may not qualify if…
- Gastric Ulcers
- Inflammatory Bowel Disease (IBD) or Irritable Bowel Syndrome (IBS)
- Chronic constipation/diarrhea
- Body Mass Index (BMI) > 30
- Dietary restrictions that prevent legume intake
- Currently on any medication that can affect GI transit time
- Consumption of >3 servings/week of raisins BEFORE study begins
Where it is running
- Emerging Pathogens Institiute — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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