Citicoline Effects on Cortical Membrane Structure and Function

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

The goal of this project is to determine the effects of 6-week dietary supplementation with one of two doses of citicoline (250 mg/d, 500 mg/d) or placebo on prefrontal cortical membrane dynamics (31P-MRS) and event-related functional activation (fMRI) in healthy middle-aged adults.

Key facts

Study ID

NCT02705066

Run by

Kyowa Hakko Bio Co., Ltd.

People needed

61

Starts

2016-03-01

Expected to finish

2018-07-01

Last updated by the study team

2019-05-23

Who can join

Age: 40 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Provision of written informed consent;
• Ages 40-60 years old;
• Right handed.
• If female, not pregnant (as determined by a positive pregnancy test); and agrees to use one of the following methods of birth control: abstinence from sexual intercourse, barrier (diaphragm or condom), or oral/injectable contraceptive;

You may not qualify if…

• Contraindication to an MRI scan (i.e., braces, claustrophobia, pacemaker etc);
• A history of a major medical (e.g., diabetes) or neurological illness (e.g., epilepsy);
• Body mass index (BMI) ≥ 30;
• An IQ <75 and >130;
• A positive urine drug test (nicotine dependence is permitted);
• Personal history of a DSM-5 Axis I psychiatric disorder;
• Requiring treatment with a drug which might obscure the action of the study treatment.

Where it is running

• University of Cincinnati — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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