Measuring Blood Flow Characteristics Using Dynamic Contrast Enhanced Magnetic Resonance Imaging
Completed · Not applicable
Conditions studied: Brain Injuries, Cerebrovascular Disorders
In brief
Dynamic contrast-enhanced (DCE) MRI gives quantitative and semi-quantitative information about the integrity of the vascular system and can be used to quantify blood-brain barrier (BBB) integrity. The BBB plays a pathophysiological role in diabetes, cognitive disorders such as mild cognitive impairment, Alzheimer's disease, multiple sclerosis, and chronic traumatic encephalopathy. Although dysfunctional, changes in BBB integrity for these conditions are thought to be subtle and close to intact values. Recent studies have shown it is possible measure small changes in the BBB integrity as an early sign of disease using DCE MRI. The objective of this study is to apply an optimized DCE imaging protocol and novel image post-processing to obtain new information about the BBB integrity in aging. These techniques show promise for both improving clinical diagnosis, and elucidated the physiology or various disease processes.
Key facts
- Study ID
- NCT02702635
- Run by
- Loma Linda University
- People needed
- 53
- Starts
- 2015-09-15
- Expected to finish
- 2021-05-26
- Last updated by the study team
- 2021-07-01
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Any person between the ages of 0-100 years, who is undergoing routine magnetic resonance imaging (MRI) with contrast at LLUMC.
- Or
- Any person between the ages of 18-100 years, who agrees to undergo routine magnetic resonance imaging (MRI) with contrast at LLUMC.
You may not qualify if…
- Electronic or metal implant that is not MRI safe, pregnancy or claustrophobia
- Not eligible for contrast agent injection (reduced renal function, GFR < 30 mL/min)
Where it is running
- Loma Linda University Medical Center — Loma Linda, California, United States
Full record on ClinicalTrials.gov
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