Brain Mechanisms for Language Processing in Adolescents With Autism Spectrum Disorder
Completed
Conditions studied: Autism Spectrum Disorders
In brief
The main goal of our study is to find out why some people with Autism Spectrum Disorder (ASD) do not develop verbal abilities or remain minimally-verbal throughout adolescence and adulthood. Current research focuses on investigating brain differences related to processing sounds and initiating speech in adolescents and young adults with ASD varying in language skills, compared to adolescents who do not have ASD, in order to clarify whether atypical processes of auditory perception, perceptual organization and/or neural oscillation patterns may explain why some individuals with ASD fail to acquire functional speech.
Key facts
- Study ID
- NCT02700074
- Run by
- Boston University Charles River Campus
- People needed
- 88
- Starts
- 2015-02-01
- Expected to finish
- 2019-08-30
- Last updated by the study team
- 2020-01-27
Who can join
Age: 14 and older, up to 21. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Between the ages of 14 and 21
- Minimally verbal (which is defined as having fewer than 10 words/phrases used communicatively during the Autism Diagnostic Observation Schedule (ADOS) assessment
- Demonstrated minimal progress in speech acquisition despite having participated in speech therapy for at least 18 months
- Diagnosis of Autism Spectrum Disorder (ASD)
- Verbal but language impaired (defined as more than 1.25 standard deviation below the mean on the clinical evaluation of language fundamentals - Fourth edition (CELF-4))
- Has normal language scores (on the CELF-4)
- Is typically developing with no history of psychiatric or neurological disorders
You may not qualify if…
- Has contraindications to having a magnetic resonance imaging (MRI) scan (e.g. electronic/ferromagnetic implant, clips, stents, existing or planned major dental work)
- Has a history of significant neurological diseases
- Has a history of sensory impairment (e.g., hearing impairment)
- Has a history of disorders other than ASD
- Is currently taking antipsychotic medications.
Where it is running
- Boston University — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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