PEEP as Rescue Therapy for Asthmatics With Elevated BMI

Completed · Phase 1/Phase 2

Conditions studied: Asthma

In brief

The purpose of this study is to test the effect of increasing lung volume with a simple hand-held device to both prevent, and also to relieve, airway constriction in people with asthma and a BMI ≥ 30 kg/m2. Twenty people with late onset non-allergic asthma and a BMI of ≥ 30 kg/m2 will be recruited. The efficacy of elevating lung volume on both preventing and reversing bronchoconstriction will be tested. Lung volume will be modulated by breathing out against a small level of resistance (positive expiratory pressure).

Key facts

Study ID

NCT02696980

Run by

University of Vermont

People needed

18

Starts

2016-04-01

Expected to finish

2019-06-01

Last updated by the study team

2024-07-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• PC20 to methacholine < 16 mg/ml
• Asthma diagnosis when ≥ 18 years of age
• Serum Immunoglobulin E < 100 IU/ml
• Ages ≥ 18 years
• BMI ≥ 30 kg/m2

You may not qualify if…

• Asthma exacerbation (defined as a hospitalization, ED visit, urgent care visit for asthma or new corticosteroids for asthma) in prior 6 weeks.
• Forced Expiratory Volume in 1 second < 60 % predicted
• Other significant disease that in the opinion of the investigator would interfere with study
• Inability to perform required testing.
• Smoking within last 6 months.
• ≥ 20 pack year smoking history
• Inability to provide informed consent
• Pregnancy

Where it is running

• Vermont Lung Center — Colchester, Vermont, United States

Full record on ClinicalTrials.gov

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