Effectiveness of Nurse-delivered Care for Adherence/Mood in HIV in South Africa

Completed · Not applicable

Conditions studied: Immunodeficiency Virus, Human, Depressive Symptoms

In brief

The purpose of this study is to conduct a two-arm effectiveness trial in Cape Town, South Africa of a Xhosa-adapted, nurse-delivered, cognitive behavioral therapy (CBT) treatment for depression and adherence, integrated into the HIV care setting in patients with HIV who did not achieve viral suppression from first-line treatment. The CBT treatment will be compared to enhanced usual care (Enhanced Treatment As Usual - ETAU) on study endpoints (as described in study endpoints section below).

Key facts

Study ID

NCT02696824

Run by

University of Miami

People needed

161

Starts

2016-07-19

Expected to finish

2020-06-09

Last updated by the study team

2021-01-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• HIV-seropositive
• Current diagnosis of depression
• Did not attain viral suppression from first-line ARV per local clinic standard

You may not qualify if…

• Unable or unwilling to provide informed consent.
• Active untreated, major mental illness (untreated psychosis or mania) that would interfere with CBT-AD.
• Has not received CBT for depression.
• Less than 18 years of age.

Where it is running

• University of Miami — Miami, Florida, United States
• The General Hospital Corp dba Massachusetts General Hospital — Boston, Massachusetts, United States
• University of Cape Town — Cape Town, South Africa

Full record on ClinicalTrials.gov

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