Testing Glial Pathways to HAAF in Human Subjects Using Carbon 13 Magnetic Resonance Spectroscopy

Completed

Conditions studied: Diabetes Complications, Hypoglycemia

In brief

Hypoglycemia-associated autonomic failure (HAAF), a condition commonly developed in diabetic patients, which causes them to have severely low blood sugar levels. This condition makes clinical management of blood sugar in diabetic patients very challenging. This research seeks to better understand how diabetic patients develop HAAF, and what can be done to prevent it.

Key facts

Study ID

NCT02690168

Run by

Pennington Biomedical Research Center

People needed

6

Starts

2016-02-01

Expected to finish

2017-07-01

Last updated by the study team

2021-07-19

Who can join

Age: 18 and older, up to 40. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Male
• BMI 20.0-24.9 kg/m2
• 18-40 years old
• Willing to reside at Pennington Biomedical for 4 days

You may not qualify if…

• Type 1 diabetes mellitus
• Type 2 diabetes mellitus
• Fasting glucose ≥ 110 mg/dL (determined at screening visit)
• Hyperketonuria >15 mg/dL, (determined at screening visit)
• Contraindication to MRI
• History of or current eating disorder
• History of obsessive compulsive disorder
• Current use of any medication (excluding over-the-counter pain medication)
• Contraindication to prolonged fasting
• Consume >10 alcoholic drinks/week

Where it is running

• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States

Full record on ClinicalTrials.gov

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