TMS Modulation of Insula-related Brain Networks
Completed · Not applicable
Conditions studied: Healthy Subjects
In brief
The purpose of this study is to investigate the modulatory effects of repetitive transcranial magnetic stimulation (rTMS) on functional connectivity with the insula. Functional connectivity (FC) measures the interaction between brain regions, and recent neuroimaging studies have used FC to investigate how addiction affects FC among pertinent brain regions. rTMS, which can excite cortical neurons, has shown promise as a method to manipulate brain connectivity and could be used therapeutically to treat addiction. However, investigators first need more information on brain FC and how it relates to behavior, in order to guide rTMS target selection.
Key facts
- Study ID
- NCT02689323
- Run by
- Duke University
- People needed
- 12
- Starts
- 2016-03-01
- Expected to finish
- 2016-11-04
- Last updated by the study team
- 2017-06-20
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- generally healthy
- between the ages of 18-55
- right-handed
You may not qualify if…
- significant health problems (e.g., current and uncontrolled liver, lung, or heart problems) or presence of medical illness likely to alter brain morphology (including history of seizure, history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, and known structural brain lesion)
- current diagnosis of Axis I psychiatric disorders (e.g., depression, anxiety disorder, schizophrenia)
- meet DSM-5 criteria for current substance use disorder other than nicotine
- use of psychoactive medications that would result in a positive urine drug screen
- Current use of medications known to lower the seizure threshold
- positive breath alcohol concentration
- presence of conditions that would make MRI unsafe (e.g., metal implants, pacemakers)
- among women, a positive urine pregnancy test
- vision that cannot be corrected to 20/40
Where it is running
- Duke University — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.