Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors

Stopped early · Phase 2

Conditions studied: Germ Cell Tumors, Testis Cancer, Testicular Cancer, Embryonal Carcinoma, Nonseminomatous Germ Cell Tumor

In brief

This is a Phase II study to evaluate the activity of brentuximab vedotin in relapsed/refractory non-seminomatous germ cell tumors (NSGCT).

Key facts

Study ID

NCT02689219

Run by

Nabil Adra

People needed

18

Starts

2016-03-09

Expected to finish

2019-01-23

Last updated by the study team

2019-12-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject must meet all of the following applicable inclusion criteria to participate in this study:
• Age ≥ 18 years at the time of informed consent.
• Patients with histologically or serologically confirmed relapsed/refractory non-seminoma germ cell tumor, (i.e., embryonal carcinoma, choriocarcinoma, or yolk sac tumors) including female GCT and primary mediastinal NSGCT.
• Patients must have progressed after prior high dose chemotherapy (HDCT) treatment, been deemed not to be a candidate for high dose chemotherapy or refused high-dose chemotherapy, and be considered incurable by other standard therapies including further chemotherapy or surgery. There is no maximum allowable number of previous therapies.
• "Failure" of prior therapy is defined as:
• A >25% increase in the products of perpendicular diameters of measurable tumor masses during prior therapy which are not amenable to surgical resection.
• The presence of new tumors which are not amenable to surgical resection.
• An increase in AFP or beta-hCG (two separate determinations at least one week apart are required if rising tumor markers are the only evidence of failure).
• NOTE: Patients with clinically growing "teratoma" (normal declining tumor markers and radiographic or clinical progression) should be considered for surgery.
• Patients must have evidence of recurrent or metastatic carcinoma by one or more of the following:
• i) The appearance of metastatic disease by standard imaging techniques ii) The appearance of rising serum tumor marker, AFP or beta-hCG NOTE: If a rising tumor marker is the only evidence of progressive disease, at least 2 consecutive rising values at least one week apart are needed. Patients with only evidence of disease is rising tumor marker AFP and beta-hCG will be provided alternate causes of increased serum levels of these markers are not present, such as cross reaction with luteinizing Hormone (LH) (that can be tested if needed by testosterone suppression of LH), hepatitis, use of marijuana or second primary tumor, etc.
• Patients with primary medistinal non seminomatous germ cell tumor are eligible if they have received first line platinum based chemotherapy and their recurrence is not amenable to surgical resection based on the treating physician expert opinion.
• Patients with late relapse (>2 years) of non seminomatous germ cell tumors are eligible if they have received first line platinum based chemotherapy and their recurrence is not amenable to surgical resection based on the treating physician expert opinion.
• Patients with brain metastases are allowed onto the study as long as patients have completed their treatment for brain metastasis, no longer require corticosteroids, and are asymptomatic. Subjects with neurological symptoms should undergo a head CT scan or brain MRI to exclude brain metastasis, at the discretion of the treating physician.
• Patients with ECOG performance status of 0-2.
• Adequate organ and marrow function as defined below:
• Hemoglobin ≥ 8 g/dL
• Absolute neutrophil count ≥ 1,000/mm3
• Platelet count ≥ 75,000/mm3
• Total bilirubin ≤ 1.5 × ULN except patients with documented Gilbert's syndrome (≤ 3 × ULN)
• Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN; for patients with hepatic metastases, ALT and AST ≤ 5 × ULN
• Calculated creatinine clearance ≥ 30 mL/min as determined by the Cockcroft-Gault equation.
• Patients who are willing and able to comply with the protocol and study procedures including willingness to undergo tumor biopsy for tumor cells before therapy to assess for CD30 status (unless archival tumor tissue from orchiectomy or other previous sample is not obtainable despite efforts to do so and a fresh tumor biopsy is not feasible).
• Females of childbearing potential must not be pregnant or breast-feeding. Male and female patients of reproductive potential must agree to use two forms of highly effective contraception from the screening visit through 28 days after the last dose of study drug. Acceptable forms of effective contraception include:
• Oral, injected or implanted hormonal methods of contraception.

You may not qualify if…

• Subjects meeting any of the criteria below may not participate in the study:
• Patients with pure seminoma.
• Patients with pure teratoma.
• Chemotherapy within 2 weeks of initiating study treatment. There is no maximum allowable number of previous therapies.
• Major surgery within 3 weeks of starting study treatment. There is no minimum time requirement for minor procedures such as biopsy or vascular access placement.
• Radiation within 2 weeks of starting study treatment.
• ≥ Grade 3 neuropathy at the time of enrollment.
• Pregnancy or breast-feeding.
• Previous treatment with any anti-CD30 directed therapy.

Where it is running

• USC/Norris Comprehensive Cancer Center — Los Angeles, California, United States
• Indiana University Health Hospital — Indianapolis, Indiana, United States
• Indiana University Health Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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