Healing of the Esophageal Mucosa After RFA of Barrett's Esophagus

Completed · Not applicable

Conditions studied: Barrett Esophagus

In brief

Radiofrequency ablation (RFA) is a mainstay of treatment for patients who have Barrett's esophagus (BE) with dysplasia. For unclear reasons, Barrett's esophagus recurs after successful RFA treatment in approximately 1/3 of patients. The aim of this study is to characterize the healing process of the esophageal mucosa, histologically and at the molecular level, after RFA for non-dysplastic and dysplastic Barrett's esophagus.

Key facts

Study ID

NCT02688114

Run by

Dallas VA Medical Center

People needed

8

Starts

2017-10-18

Expected to finish

2020-01-29

Last updated by the study team

2023-09-11

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Barrett's esophagus

You may not qualify if…

• inability to provide informed consent
• esophageal varices
• treatment with warfarin
• coagulopathy that precludes safe biopsy of the esophagus (including platelet count <100,000/mm3, INR (international normalized ratio) >1.5)
• allergy to fluorescein sodium
• comorbidity that precludes safe participation in the study
• pregnancy or breastfeeding status

Where it is running

• Baylor Scott and White Research Institute — Dallas, Texas, United States
• Dallas VA Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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