Efficacy, Safety and Tolerability of PF-06649751 in Parkinson's Disease Patients With Motor Fluctuations

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Parkinson Disease

In brief

The purpose of this study is to evaluate the efficacy, safety and tolerability of PF-06649751 in Parkinson's disease patients who experience motor-fluctuations.

Key facts

Study ID

NCT02687542

Run by

Pfizer

People needed

108

Starts

2016-03-03

Expected to finish

2017-11-10

Last updated by the study team

2020-11-23

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Females of non-childbearing potential and/or male subjects between the ages of 40 and 85 years, inclusive.
• Clinical diagnosis of Parkinson's disease.
• Able to refrain from any Parkinson's disease medication not permitted by the protocol.

You may not qualify if…

• Female of childbearing potential
• History or presence of atypical Parkinsonian syndrome.
• History of surgical intervention for Parkinson's disease.
• Severe acute or chronic medical or psychiatric condition or laboratory abnormality.
• Any condition possibly affecting drug absorption.
• Participation in other studies involving investigational drug(s), or treatment with any investigational drug within 30 days.

Where it is running

• St Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
• Arcadia Neurology Center — Arcadia, California, United States
• Faculty Physicians and Surgeons of Loma Linda University School of Medicine — Loma Linda, California, United States
• Hoag Memorial Hospital Presbyterian — Newport Beach, California, United States
• Hoag Memorial Hospital — Newport Beach, California, United States
• SC3 Research Group, Inc — Pasadena, California, United States
• Neurosearch-Torrance — Torrance, California, United States
• Associated Neurologists of Southern Connecticut, PC — Fairfield, Connecticut, United States
• Parkinson's Disease and Movement Disorders Center of Boca Raton — Boca Raton, Florida, United States
• University of Florida Center for Movement Disorders and Neurorestoration — Gainesville, Florida, United States
• Neurology Associates of Ormond Beach — Ormond Beach, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Vero Beach Neurology and Research Institute — Vero Beach, Florida, United States
• Atlanta Center for Medical Research — Atlanta, Georgia, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Indiana University Health Neuroscience Center — Indianapolis, Indiana, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• CRI Worldwide, LLC — Marlton, New Jersey, United States
• Dent Neurologic Institute — Amherst, New York, United States
• Dent Neurosciences Research Center ,Inc. DBA Dent Neurologic Institute — Amherst, New York, United States
• Dent Neurologic Institute — Orchard Park, New York, United States
• Duke University Medical center — Durham, North Carolina, United States
• Duke University/Duke Neurology/Department of Neurology — Durham, North Carolina, United States
• Wake Research Associates, LLC — Raleigh, North Carolina, United States
• Xenoscience, Inc — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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