PARTNER II Trial: S3iCAP

Completed · Not applicable

Conditions studied: Aortic Stenosis

In brief

Following completion of enrollment in the PARTNER II SAPIEN 3 intermediate risk trial, this trial provided continued access to treatment for subjects with severe aortic stenosis who were at intermediate surgical risk.

Key facts

Study ID

NCT02687035

Run by

Edwards Lifesciences

People needed

1822

Starts

2015-01-01

Expected to finish

2018-12-01

Last updated by the study team

2021-04-08

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must be covered by Medicare. This will enable Edwards to link to the CMS database for long term follow-up through 5 years. No other insurance provider will be accepted.
• Assessment of intermediate surgical risk defined as STS 4-8% or heart team assessment of intermediate risk factors.
• Patient has senile degenerative aortic valve stenosis with echocardiographically derived criteria: mean gradient > 40 mmHg or jet velocity greater than 4.0 m/s and an initial aortic valve area (AVA) of < 0.8 cm2 or indexed EOA < 0.5 cm2/m2. Qualifying echo must be within 60 days of the date of the procedure.
• Aortic valve annulus area range (273mm2-680 mm2) per 3D imaging (echo, CT, or MRI).
• Patient is symptomatic from his/her aortic valve stenosis, as demonstrated by NYHA Functional Class II or greater.
• The heart team agrees (and verified in the case review process) that valve implantation will likely benefit the patient.
• Heart team agrees (a priori) on treatment strategy for concomitant coronary disease (if present).
• The study patient or the study patient's legal representative has been informed of the nature of the study, agrees to its provisions and has provided written informed consent as approved by the Institutional Review Board (IRB) of the respective clinical site.
• The study patient agrees to comply with all required post-procedure follow-up visits including annual visits through 5 years and analysis close date visits, which will be conducted as a phone follow-up.

You may not qualify if…

• Heart team assessment of inoperability (including examining cardiac surgeon).
• Evidence of an acute myocardial infarction ≤ 1 month (30 days) before the intended treatment [(defined as: Q wave MI, or non-Q wave MI with total CK elevation of CK-MB ≥ twice normal in the presence of MB elevation and/or troponin level elevation (WHO definition)].
• Aortic valve is a congenital unicuspid or congenital bicuspid valve, or is non-calcified.
• Mixed aortic valve disease (aortic stenosis and aortic re-regurgitation with predominant aortic regurgitation >3+).
• Pre-existing mechanical or bioprosthetic valve in any position.
• Complex coronary artery disease:
• Unprotected left main coronary artery
• Syntax score > 32 (in the absence of prior revascularization)
• Any therapeutic invasive cardiac procedure resulting in a permanent implant that is performed within 30 days of the index procedure (unless part of planned strategy for treatment of concomitant coronary artery disease). Implantation of a permanent pacemaker or ICD is not considered exclusion criteria.
• Any patient with a balloon valvuloplasty (BAV) < 30 days of the procedure (unless BAV is a bridge to procedure after a qualifying ECHO).
• Patients with planned concomitant surgical or transcatheter ablation for atrial fibrillation.
• Leukopenia (WBC < 3000 cell/mL), acute anemia (Hgb < 9 g/dL), thrombocytopenia (Plt < 50,000 cell/mL).
• Hypertrophic cardiomyopathy with or without obstruction (HOCM).
• Hemodynamic or respiratory instability requiring inotropic support, mechanical ventilation or mechanical heart assistance within 30 days of screening evaluation.
• Need for emergency surgery for any reason.
• Severe ventricular dysfunction with LVEF < 20%.
• Echocardiographic evidence of intracardiac mass, thrombus or vegetation.
• Active upper GI bleeding within 3 months (90 days) prior to procedure.
• A known contraindication or hypersensitivity to all anticoagulation regimens, or inability to be anticoagulated for the study procedure.
• Native aortic annulus size < 16 mm or > 28mm as measured by echocardiogram.
• Clinically (by neurologist) or neuroimaging confirmed stroke or transient ischemic attack (TIA) within 6 months (180 days) of the procedure.
• Renal insufficiency (creatinine > 3.0 mg/dL) and/or renal replacement therapy at the time of screening.
• Estimated life expectancy < 24 months (730 days) due to carcinomas, chronic liver disease, chronic renal dis-ease or chronic end stage pulmonary disease.
• Expectation that patient will not improve despite treatment of aortic stenosis.
• Significant aortic disease, including marked tortuosity (hyperacute bend), aortic arch atheroma [especially if thick (> 5 mm), protruding or ulcerated] or narrowing (especially with calcification and surface irregularities) of the abdominal or thoracic aorta, severe "unfolding" and tortuosity of the thoracic aorta. (Transfemoral)

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Stanford Hospital and Clinics — Palo Alto, California, United States
• Mercy General Hospital — Sacramento, California, United States
• University of Colorado Hospital — Denver, Colorado, United States
• Washington Hospital Center DC — Washington D.C., District of Columbia, United States
• Morton Plant Hospital — Clearwater, Florida, United States
• University of Florida — Gainesville, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Northwestern University — Chicago, Illinois, United States
• Rush University Medical Center — Chicago, Illinois, United States
• NorthShore University HealthSystem Research Institute — Evanston, Illinois, United States
• Prairie Education and Research Cooperative — Springfield, Illinois, United States
• Indiana University Health-Methodist Hospital — Indianapolis, Indiana, United States
• St. Vincent Medical Group, Inc./ St. Vincent Heart Center of Indiana, LLC — Indianapolis, Indiana, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• University of Louisville Jewish Hospital — Louisville, Kentucky, United States
• Ochsner Clinic Foundation — New Orleans, Louisiana, United States
• MedStar Union Memorial Hospital — Baltimore, Maryland, United States
• University of Maryland Medical Center — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• University of Michigan Hospital and Health Systems — Ann Arbor, Michigan, United States
• Henry Ford Hospital — Detroit, Michigan, United States
• William Beaumont Hospital — Royal Oak, Michigan, United States
• Scripps Green Hospital — La Jolla, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.