Zimura in Participants With Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Geographic Atrophy, Dry Age-Related Macular Degeneration

In brief

The objectives of this study were to evaluate the safety and efficacy of Zimura intravitreal (IVT) administration when administered in participants with geographic atrophy (GA) secondary to dry age-related macular degeneration (AMD).

Key facts

Study ID

NCT02686658

Run by

IVERIC bio, Inc.

People needed

286

Starts

2015-12-15

Expected to finish

2020-04-23

Last updated by the study team

2025-06-10

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants of either gender aged ≥ 50 years
• Diagnosis of Non-foveal GA secondary to dry AMD

You may not qualify if…

• Evidence of Choroidal Neovascularization (CNV)
• GA secondary to any condition other than AMD
• Any prior treatment for AMD or any prior intravitreal treatment for any indication in either eye, except oral supplements of vitamins and minerals
• Any intraocular surgery or thermal laser within three (3) months of trial entry
• Any prior thermal laser in the macular region, regardless of indication
• Any ocular or periocular infection in the twelve (12) weeks
• Previous therapeutic radiation in the region of the study eye
• Any sign of diabetic retinopathy in either eye

Where it is running

• Study site — Tucson, Arizona, United States
• Study site — Tucson, Arizona, United States
• Study site — Campbell, California, United States
• Study site — Fresno, California, United States
• Study site — Fullerton, California, United States
• Study site — La Jolla, California, United States
• Study site — Mountain View, California, United States
• Study site — Redlands, California, United States
• Study site — Sacramento, California, United States
• Study site — Sacramento, California, United States
• Study site — Santa Ana, California, United States
• Study site — Denver, Colorado, United States
• Study site — Altamonte Springs, Florida, United States
• Study site — Boynton Beach, Florida, United States
• Study site — Melbourne, Florida, United States
• Study site — St. Petersburg, Florida, United States
• Study site — Stuart, Florida, United States
• Study site — Winter Haven, Florida, United States
• Study site — Augusta, Georgia, United States
• Study site — Marietta, Georgia, United States
• Retina Consultants of Hawaii — ‘Aiea, Hawaii, United States
• Study site — West Des Moines, Iowa, United States
• Study site — Shawnee Mission, Kansas, United States
• Study site — Wichita, Kansas, United States
• Study site — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.