Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS

Completed

Conditions studied: C9ORF72 Amyotrophic Lateral Sclerosis (ALS)

In brief

This research study is being performed to better understand a specific form of Amyotrophic Lateral Sclerosis (ALS) caused by a mutation (or abnormality) of the C9ORF72 gene. This mutation is the most common genetic cause of ALS, and is present in 40% of ALS patients with a family history of ALS and 5-10% of ALS patients without a family history of ALS.

Key facts

Study ID

NCT02686268

Run by

Washington University School of Medicine

People needed

128

Starts

2015-02-01

Expected to finish

2018-10-02

Last updated by the study team

2021-07-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Cedars Sinai Medical Center — Los Angeles, California, United States
• Johns Hopkins — Baltimore, Maryland, United States
• University of Massachusetts — Amherst, Massachusetts, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Washington University in St. Louis — St Louis, Missouri, United States
• Columbia University Medical Center — New York, New York, United States
• Sentara Health Care / Sentara Neurology Specialists — Virginia Beach, Virginia, United States
• UMC Utrecht — Utrecht, Netherlands

Full record on ClinicalTrials.gov

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