Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral Nutrition

Completed · Phase 3

Conditions studied: Short Bowel Syndrome

In brief

Teduglutide is approved for treatment of adults with short bowel syndrome (SBS). The purpose of this study is to evaluate the safety and efficacy of teduglutide in children up to the age of 17 with SBS who are dependent on parenteral support. Subjects may choose whether to receive the study drug or to participate in a standard-of-care arm. All participants who complete the study may be eligible to receive the study drug in a long-term extension study.

Key facts

Study ID

NCT02682381

Run by

Shire

People needed

59

Starts

2016-06-23

Expected to finish

2017-08-18

Last updated by the study team

2021-06-09

Who can join

Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Informed consent by a parent or guardian or emancipated minor prior to any study-related procedures
• When applicable, an informed assent by the subject (as deemed appropriate by the Ethics Committee/Institutional Review Board) prior to any study-related procedures
• Current history of SBS as a result of major intestinal resection, (eg, due to necrotizing enterocolitis, midgut volvulus, intestinal atresia, or gastroschisis)
• Short bowel syndrome that requires PN/IV support that provides at least 30% of caloric and/or fluid/electrolyte needs prior to screening
• Stable PN/IV support, defined as inability to significantly reduce PN/IV support, usually associated with minimal or no advance in enteral feeds (ie, 10% or less change in PN or advance in feeds) for at least 3 months prior to and during screening, as assessed by the investigator.
• Sexually active female subjects of child-bearing potential (in the teduglutide treatment arm only) must use medically acceptable methods of birth control during and 4 weeks after the treatment period

You may not qualify if…

• Subjects who are not expected to be able to advance oral or tube feeding regimens
• Serial transverse enteroplasty or any other bowel lengthening procedure performed within 3 months of screening
• Known clinically significant untreated intestinal obstruction contributing to feeding intolerance and inability to reduce parenteral support
• Unstable absorption due to cystic fibrosis or known DNA abnormalities
• Severe, known dysmotility syndrome, such as pseudo-obstruction or persistent, severe, active gastroschisis-related dysmotility, that is the primary contributing factor to feeding intolerance and inability to reduce parenteral support, prior to screening. Dysmotility is defined as severe if it is expected to limit the advancement of enteral feeding.
• Evidence of clinically significant obstruction on upper GI series done within 6 months prior to screening.
• Major GI surgical intervention including significant intestinal resection within 3 months prior to the screening visit (insertion of feeding tube, anastomotic ulcer repair, minor intestinal resections ≤ 10 cm, or endoscopic procedure is allowed).
• Unstable cardiac disease, congenital heart disease or cyanotic disease, with the exception of subjects who had undergone ventricular or atrial septal defect repair, and patent ductus arteriosus (PDA) ligation.
• History of cancer or clinically significant lymphoproliferative disease, not including resected cutaneous basal or squamous cell carcinoma, or in situ non aggressive and surgically resected cancer.
• Pregnant or lactating female subjects (in the teduglutide treatment arm only).
• Participation in a clinical study using an experimental drug (other than glutamine or Omegaven) within 3 months or 5.5 half-lives of the experimental drug, whichever is longer, prior to screening, and for the duration of the study.
• Previous use of teduglutide or native/synthetic glucagon-like peptide-2 (GLP-2)
• Previous use of glucagon-like peptide-1 analog or human growth hormone within 3 months prior to screening
• Previous use of octreotide, or dipeptidyl peptidase-4 (DPP-4) inhibitors within 3 months prior to screening
• Subjects with active Crohn's disease who had been treated with biological therapy (eg, antitumor necrosis factor [anti-TNF]) within the 6 months prior to the screening visit
• Subjects with inflammatory bowel disease (IBD) who require chronic systemic immunosuppressant therapy that had been introduced or changed during the 3 months prior to screening
• More than 3 SBS-related or PN-related hospital admissions (eg, documented infection-related catheter sepsis, clots, bowel obstruction, severe water-electrolyte disturbances) within 3 months prior to the screening visit
• Any major unscheduled hospital admission which affects parenteral support requirements within 1 month prior to or during screening, excluding uncomplicated treatment of bacteremia, central line replacement/repair, or issues of similar magnitude in an otherwise stable subject
• Body weight < 10 kg at the screening and baseline visits
• Signs of active severe or unstable, clinically significant hepatic impairment during the screening period, as indicated by any of the following laboratory test results :
• Total bilirubin (TBL) ≥ 2 x upper limit of normal (ULN)
• Aspartate aminotransferase (AST) ≥ 7x ULN
• Alanine aminotransferase (ALT) ≥ 7x ULN
• For subjects with Gilbert's disease:
• Indirect (unconjugated) bilirubin ≥ 2x ULN

Where it is running

• Children's Hospital Los Angeles - RHU — Los Angeles, California, United States
• UCLA Dept. of Medicine — Los Angeles, California, United States
• UCSF Benioff Children's Hospital — San Francisco, California, United States
• Georgetown Children's Research Network — Washington D.C., District of Columbia, United States
• Ann & Robert H Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
• Riley Hospital for Children — Indianapolis, Indiana, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• The Nebraska Medical Center — Omaha, Nebraska, United States
• Children's Hospital GI Nutrition — New York, New York, United States
• Montefiore Medical Center Child Spc — The Bronx, New York, United States
• Duke Medical Center — Durham, North Carolina, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Cleveland Clinic Pediatric Specialists — Cleveland, Ohio, United States
• University of Pennsylvania Medical Center — Philadelphia, Pennsylvania, United States
• Children's Medical Center Dallas — Dallas, Texas, United States
• Texas Children's Hospital — Houston, Texas, United States
• Seattle Children's Hospital — Seattle, Washington, United States
• University of Wisconsin School of Medicine and Public Health — Madison, Wisconsin, United States
• Cliniques Universitaires Saint-Luc — Brussels, Belgium
• Walter C. Mackenzie Health Science Center — Edmonton, Alberta, Canada
• British Columbia Children's & Women's Hospital Center — Vancouver, British Columbia, Canada
• The Hospital for Sick Children — Toronto, Ontario, Canada
• Helsingin yliopistollinen keskussairaala — Helsinki, Finland
• Universitaetsklinikum Tuebingen — Tübingen, Baden Wuertternberg, Germany
• Ospedale Pediatrico Bambino Gesu — Roma, Italy

Full record on ClinicalTrials.gov

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