Prospective Evaluation of Patient Reported Xerostomia After Whole Brain Radiation

Completed

Conditions studied: Xerostomia

In brief

The goal of this prospective observational study is to investigate whether whole brain radiation leads to measurable xerostomia from parotid gland toxicity.

Key facts

Study ID

NCT02682199

Run by

UNC Lineberger Comprehensive Cancer Center

People needed

100

Starts

2015-10-01

Expected to finish

2018-08-30

Last updated by the study team

2019-09-23

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients to be treated with whole brain radiation in 10-15 fractions to a total dose of 25-37.5 Gy for a diagnosis of brain metastases from any disease site or as prophylaxis in the treatment of potentially subclinical intracranial disease (e.g. from small cell lung cancer).
• Has not had prior radiation that would have exposed the parotids to a significant (estimated >10 Gy mean parotid dose) level of radiation within the past one year. Patients receiving prior stereotactic radiosurgery for brain metastasis are eligible for inclusion in this trial as this form of radiation is highly conformal and exposes the parotids to minimal (estimated <1 Gy) radiation.
• Greater than or equal to 18 years of age (no upper age limit).
• Informed consent obtained.

You may not qualify if…

• Patients receiving whole brain radiation without the use of a CT-based planning simulation.
• Patients who are on medications known to cause dry mouth, such as anticholinergics.
• Physically unable to communicate by paper or phone to complete the study survey.
• Prisoners.

Where it is running

• University of North Carolina at Chapel Hill, Department of Radiation Oncology — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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