The Use of Airway Clearance Devices in ALS
Completed · Not applicable
Conditions studied: Amyotrophic Lateral Sclerosis
In brief
The investigator is examining the use of one airway clearance medical device compared to the use of two airway clearance medical devices together in patients with amyotrophic lateral sclerosis (ALS). More specifically, the investigator wants to know how effective the use of either a mechanical High Frequency Chest Compression (HFCC) device is on its own or the use of both a mechanical High Frequency Chest Compression (HFCC) device and Cough Assist together to maintain a healthy airway and clear secretions. The first device is a passive form of mechanical High Frequency Chest Compression (HFCC), which was designed to help clear the airway of mucus and other secretions through mechanical knocking of the chest area. The second device, called a Cough Assist, aids patients to clear mucus and secretions that they would otherwise be unable to clear with coughing. This study will enroll up to 20 people in total at CSMC.
Key facts
- Study ID
- NCT02682030
- Run by
- Cedars-Sinai Medical Center
- People needed
- 5
- Starts
- 2016-03-01
- Expected to finish
- 2018-12-01
- Last updated by the study team
- 2020-08-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Suspected, possible, probable, Probable (Lab-Supported), or Definite ALS according to El Escorial Criteria
- Males and females age 18 and above
- Novel to airway clearance device use
- Forced vital capacity ≤ 75% of predicted
You may not qualify if…
- Any contraindication for pulmonary ventilation scan including allergy to radioisotopes
- Any contraindication for use of a pulmonary clearance device
- Susceptibility to pneumothorax
- Recent (within 30 days) barotrauma
- Unstable head or neck injury
- Active hemorrhage with hemodynamic instability
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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