Epidural Analgesia Use in Pancreatic Resections

Completed · Phase 1

Conditions studied: Cancer of Pancreas, Cancer of the Pancreas, Pancreas Cancer, Pancreas Neoplasms, Pancreatic Cancer

In brief

The rationale for this study is to investigate the benefits of epidural analgesia in pancreatic resections in a prospective, single blind, randomized control trial. This study will evaluate both short and long-term outcomes related to epidural analgesia, providing a longitudinal and comprehensive perspective to the advantages and disadvantages of this technique. The investigators hypothesize that the use of epidural analgesia reduces a patient's consumption of morphine or morphine-equivalent in the post-operative period following pancreatic resections.

Key facts

Study ID

NCT02681796

Run by

Washington University School of Medicine

People needed

23

Starts

2016-06-07

Expected to finish

2020-02-07

Last updated by the study team

2020-03-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing pancreatic resection.
• Age ≥18 years old.
• Able to understand and sign an Institutional Review Board (IRB)-approved informed consent form.

You may not qualify if…

• Indication for operative intervention being chronic pancreatitis.
• Currently on warfarin with an INR≥1.4 or clopidogrel that cannot be discontinued 7 days prior to surgery;
• Most recent INR prior to surgery >1.4
• Most recent platelet count prior to surgery <70,000/mcl
• Chronic opioid use as defined by use of more than 20mg oxycodone, or equivalent, daily.
• History of pre-existing neuropathic pain conditions.
• Not giving consent for study participation.
• Known medical history of significant psychiatric or cognitive impairment
• History of HIV, Hepatitis B, and/or Hepatitis C

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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