Understanding the Molecular and Genetic Differences Between Germ Cell Tumor at the Time of the Initial Diagnosis and at Late Relapse
Completed
Conditions studied: Neoplasms, Germ Cell and Embryonal
In brief
The current proposal is a pilot study. The Investigators plan to use next generation genome sequencing (NGGS) to define the molecular and genetic profiles of 3 cases of germ cell tumor (GCT) (with a component of yolk sac tumor) at the time of the initial diagnosis and 3 cases of late relapse GCT's, which are characterized by yolk sac tumor (and AFP secreting) predominant disease. Investigators seek to demonstrate the feasibility of obtaining tissue biopsies (either archived or new biopsy) and utilization of NGGS in studying the molecular and genetic relationships between GCT's (with a component of yolk sac tumor) at the time of diagnosis and GCT's at the time of late relapse. This study will also provide preliminary information on genetic alterations, which may be a hypothesis for generating another study.
Key facts
- Study ID
- NCT02679950
- Run by
- Nasser Hanna
- People needed
- 6
- Starts
- 2015-11-20
- Expected to finish
- 2017-04-25
- Last updated by the study team
- 2018-08-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Indiana University Health Hospital — Indianapolis, Indiana, United States
- Indiana University Health Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
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