Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity

Completed · Not applicable

Conditions studied: Non-invasive Neuromodulation in Healthy Subjects

In brief

The aim of this project is to increase our understanding of how two different protocols of repetitive transcranial magnetic stimulation (rTMS), inhibitory (1 Hz) and excitatory (5 Hz), applied over the primary motor cortex of the presumed dominant hemisphere, affect functional connectivity and neurochemistry in the brain.

Key facts

Study ID

NCT02677740

Run by

University of Minnesota

People needed

8

Starts

2016-08-29

Expected to finish

2017-03-19

Last updated by the study team

2019-11-18

Who can join

Age: 21 and older, up to 40. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Those volunteers who are evaluated as normal and not met exclusion criteria will be potential candidates for this study.

You may not qualify if…

• The following participants will be excluded from this study, including but not limited to:
• Females
• Left handed males
• Participants who never underwent MRI at 7 Tesla
• Participants with:
• any type of bio-implant activated by mechanical, electronic, or magnetic means (e.g. cochlear implants, pacemakers, neurostimulators, bio stimulators, electronic infusion pumps.)
• any type of ferromagnetic bio-implant that could potentially be displaced or damaged, such as aneurysm clips, metallic skull plates, etc.
• non-removable piercing or permanent eyeliner
• retained metal in their body, either from a medical procedure or an injury
• Participants who:
• have been diagnosed by a physician as having a psychiatric disorder, substance abuse, neurological and/or cardiovascular disease
• have cardiac or known circulatory impairment, and/or the inability to perspire (poor thermoregulatory function)
• have hyper- or hypotension or arrhythmias
• have known conditions which can lead to emergency medical care
• had a head injury that caused them to lose consciousness for more than 30 minutes or have amnesia for more than 24 hours
• had a brain tumor or stroke
• had one or more seizures, or been given a diagnosis of epilepsy
• have a history of sleep apnea or head trauma that may have caused Traumatic Brain Injury (TBI)
• have a history of anxiety, syncope, panic attacks and/or claustrophobia
• cannot adhere to the experimental protocol for any reason
• started taking chemotherapy or immunomodulatory agents, or had any radiation treatment that could affect the brain
• are currently on any medication

Where it is running

• Center for Magnetic Resonance Research, Dept. of Radiology, University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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