POTS Adrenergic Ab (CIHR Aims #1&2)

Recruiting now

Conditions studied: Postural Tachycardia Syndrome

In brief

Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.

Key facts

Study ID

NCT02673996

Run by

University of Calgary

People needed

125

Starts

2016-01-01

Expected to finish

2030-12-31

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients who have been previously diagnosed with POTS
• Control subjects (patients not diagnosed with POTS)
• Age between 18 - 60 years
• Males and Females (Give that >80% of POTS patients are female, we will attempt to enroll a similar percentage of female control subjects)
• Able and willing to provide consent

You may not qualify if…

• Smokers
• Overt cause for postural tachycardia, i.e., acute dehydration
• Significant cardiovascular, pulmonary, hepatic, or hematological disease by history or prior testing
• Highly trained athletes
• Subjects with somatization or severe anxiety symptoms will be excluded
• Use of drospirenone (a spironolactone analogue) containing oral contraceptive agent
• Hypertension defined as supine resting BP>145/95 mmHg off medications or needing antihypertensive medication
• Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule
• Unable to give informed consent

Where it is running

• University of Calgary — Calgary, Alberta, Canada (enrolling)

Full record on ClinicalTrials.gov

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