Impact of Estrogen on Fear Extinction R61
Completed · Phase 1 · Has a placebo group
Conditions studied: Fear, Fear; Examination, Phobic
In brief
The goal of this project is to examine how estrogen may influence the resting-state connectivity and the extinction-induced activation of the fear extinction network.
Key facts
- Study ID
- NCT02673606
- Run by
- NYU Langone Health
- People needed
- 136
- Starts
- 2013-01-01
- Expected to finish
- 2019-04-15
- Last updated by the study team
- 2020-07-30
Who can join
Age: 18 and older, up to 80. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Right-handed (Edinburgh Inventory - Oldfield 1971).
- SCID diagnosis consistent with none, current or past history of Axis I psychiatric disorders.
- To be matched for age, gender, and years of education, as well as self-identified race/ethnicity.
- For naturally cycling female subjects, stage of menstrual cycle will be ascertained by history, and by serological measures.
- For women on oral contraceptives, we will identify those using 20mcg ethinyl, 2nd or 3rd generation, monophasic
You may not qualify if…
- Psychiatric, neurologic or medical condition that would interfere with study procedures or confound results, ascertained by history.
- History of seizure or significant head trauma (i.e., extended loss of consciousness, neurological sequelae, or known structural brain lesion).
- History of Axis I psychiatric diagnosis; e.g., history of substance use disorder, psychotic disorder, bipolar disorder, tic disorder, or eating disorder.
- Use of psychotropic medication within 4 weeks prior to study (within 6 weeks for fluoxetine, or other long-lived compounds; within one year for neuroleptics).
- Pregnancy (to be ruled out by urine ß-HCG).
- Metallic implants or devices contraindicating magnetic resonance imaging.
- Use of oral contraceptives or non-oral contraceptives containing estrogen and progesterone within 3 months
- History of breast cancer.
- Allergy to peanut oil.
Where it is running
- NYU School of Medicine — New York, New York, United States
Full record on ClinicalTrials.gov
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